Baylor University was awarded a $426,000 Project Grant from the National Science Foundation Division of Chemistry to directly quantify the thermodynamic cooperativities and conformations of single-strand DNA binding proteins from July 1, 2021 to June 30, 2024. The award is being used to support research under the NSF's Mathematical and Physical Sciences program (CFDA 47.049), which aims to promote progress in these scientific fields and strengthen the national scientific enterprise through...
Baylor University will receive $805,201 over four years from the National Science Foundation under the Biological Sciences federal grant program (CFDA 47.074) to study the decoupling of DNA unwinding and synthesis in the replisome and induce genome instability. This Project Grant award, made on June 1, 2021, will fund research examining how the replication machinery unwinds and copies DNA, with the goal of increasing understanding of major biological problems as described in the program...
This Project Grant from the National Institutes of Health's National Institute of General Medical Sciences, under the Biomedical Research and Research Training program (CFDA 93.859), provides $754,986 to Baylor University from September 1, 2022 through August 31, 2025. The grant supports research into the mechanisms of DNA damage processing and initiation of nucleotide excision repair. Specifically, the grant will fund experiments using cryo-electron microscopy, time-resolved fluorescence...
The University of California, Davis (UC Davis) received a $389,525 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) for a 5-year research project titled "CAREER: Mechanisms and Consequences of Epigenome-Recruited DNA Repair Systems in Plants." The project aims to study newly discovered DNA repair mechanisms in plants that could help protect critical genomic regions from harmful mutations. Researchers will leverage advanced...
This Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program provides $246,424 to the University of California, Santa Barbara (UCSB) to research the initiation of recombination at DNA double-strand breaks. The 5-year project, running from March 2025 to February 2030, aims to leverage novel methods to understand how cells choose different DNA repair mechanisms, with a focus on recombination. The research will define key steps in the recombination...
This $150,000 Project Grant awarded by the National Science Foundation's Mathematical and Physical Sciences (CFDA 47.049) program funds research at Vanderbilt University to elucidate the molecular mechanisms of DNA repair by a newly discovered bacterial enzyme. The project aims to understand how this enzyme protects microbes against toxic natural products, with the long-term goals of elucidating bacterial interstrand DNA crosslink repair pathways and discovering new genotoxic agents with...
This Project Grant award of $541,574 from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports a collaborative research project between the University of Massachusetts Medical School (UMass Medical) and the Israeli Binational Science Foundation. The project aims to investigate the effects of transcription factor binding on the accumulation of UV-induced DNA lesions and mutations within the human genome. Key aspects of the project include developing...
This Project Grant award of $136,600 from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at William Marsh Rice University to develop advanced tools for directly visualizing, quantifying, and correlating DNA dynamics, organization, and gene activity in real-time. The project aims to overcome challenges in studying these essential processes for regulating gene expression and healthy cell function, which have been implicated in various diseases. The...
Louisiana State University was awarded a $685,032 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences on June 1, 2021 to support research titled "Regulation of Transcription Coupled DNA Repair" through May 31, 2024. The grant is part of NSF's Biological Sciences program (CFDA 47.074), which aims to promote progress in the biological sciences and strengthen the nation's scientific enterprise through increased knowledge and understanding of...
The University of Iowa received a $470,000 National Science Foundation (NSF) Project Grant under the Biological Sciences program (CFDA 47.074) to conduct collaborative research on the effect of transcription factor binding on UV lesion accumulation in the human genome. The research aims to determine whether transcription factor binding enhances the frequency of DNA damage or impairs DNA repair, leading to increased mutation rates in those genomic regions. The project will develop innovative...