This National Science Foundation (NSF) Project Grant award, funded under the Integrative Activities program (CFDA 47.083), supports research on the structural mechanisms of bacterial extracellular DNA-recognition. The $216,149 award to the Board of Regents of the University of Nebraska, from July 1, 2023 to June 30, 2026, aims to identify and characterize novel DNA receptor subunits incorporated into bacterial surface appendages. The project will purify soluble protein constructs, measure...
This Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences, under the Biological Sciences federal grant program (CFDA 47.074), provides $794,803 to the University of Nebraska from July 1, 2022 to June 30, 2025. The funding supports research into the "Mechanisms of Small RNA-Mediated Silencing in Chlamydomonas" being conducted by the University of Nebraska. As part of the Biological Sciences program's goal of increasing scientific...
This National Science Foundation project grant award of $270,728 provides funding from August 1, 2022 through July 31, 2025 to support research exploring self-organization of functional nucleic acid supramolecular assemblies with stimuli responsive properties. Funded under the NSF Integrative Activities program (CFDA 47.083), the award supports the University of Nebraska at Omaha and its parent institution, the Board of Regents of the University of Nebraska, in developing a toolkit for...
This $900,000 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports research at the University of Colorado (CU) to investigate the molecular mechanisms of DNA methyltransferase 1 (DNMT1)-mediated gene silencing. The project aims to utilize structural biology, biochemistry, and cell biology methods to understand DNMT1 regulation and the mechanisms cells employ to ensure DNMT1 acts on specific DNA sequences. The research will provide...
The National Science Foundation Division of Environmental Biology awarded a $400,219 Project Grant to the Board of Regents of the University of Nebraska to support research titled "Ecological and Evolutionary Effects of Extinction and Ecosystem Engineers (E6)." The five-year grant, awarded September 1, 2021 with a completion date of August 31, 2026, will fund basic research under the Biological Sciences program (CFDA 47.074). The Biological Sciences program aims to advance...
This $120,227 project grant awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program supports research at Northeastern University to develop a new theoretical approach for studying the three-dimensional architecture and conformational ensembles of genes and gene clusters. The project aims to: (i) model the mechanics of chromatin at the gene scale, (ii) investigate how genomic conformations are affected by factors like supercoiling and...
The National Science Foundation (NSF) awarded a $563,690 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to the Board of Regents of the University of Nebraska for the project "HETEROMOLECULAR INTERFACE DESIGN FOR BETTER MULTIFERROIC MOLECULAR SPINTRONICS". The goal of this research is to develop a highly stable, energy-efficient molecular-based memory device that can potentially address the growing need for computer memory while reducing energy...
The National Science Foundation (NSF) awarded the University of New Mexico (UNM) a $500,000 Project Grant under the Computer and Information Science and Engineering (CFDA 47.070) program. The grant supports research on the design of heterochiral DNA nanostructures for biomaterials applications. The project aims to study the structure and function of these hybrid DNA materials that combine right-handed (D-DNA) and left-handed (L-DNA) forms, and to use computational modeling and experimental...
This $275,315 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports research at Purdue University to understand how the mechanical regulation of chromatin motion in the cell nucleus responds to external stimuli. The project aims to develop new imaging platforms and experimental methods to simultaneously quantify intracellular tension and chromatin dynamics under mechanical disturbance. This work has the potential to...
This $1,220,400 Project Grant awarded by the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences supports a collaborative research project between investigators in the U.S. and U.K. to better understand the regulatory mechanisms controlling mammalian gene expression. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to define the roles of different DNA regulatory elements and how they work together to precisely control gene expression....