The University of Pittsburgh received a four-year, $855,989 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences under the Biological Sciences federal grant program (CFDA 47.074). The grant will fund collaborative research between the University of Pittsburgh and other institutions to tackle functional protein states at atomic detail by integrating weighted ensemble simulations with magnetic resonance restraints. Over the period from July 2021 to June...
The National Science Foundation awarded a $138,000 Project Grant to support research activities from November 1, 2021 to October 31, 2023 under the Biological Sciences program (CFDA 47.074). The grant funding will enable the grantee to conduct research at the University of Pittsburgh aimed at furthering understanding of the evolution of gene regulatory networks through empirical and theoretical approaches. The Biological Sciences program seeks to advance the field and strengthen the national...
This NSF-BSF Project Grant award, valued at $774,534, supports the development of experimental electron paramagnetic resonance (EPR) methodology and associated simulation techniques to elucidate the sensing and transcription mechanism of a copper-inducible repressor protein (CopY) found in pathogenic bacteria. The primary objectives are to: 1) Improve the sensitivity of pulsed EPR distance measurement methods and generate orthogonal labeling schemes based on a novel site-directed spin label; and...
This federal Project Grant award of $1,211,143 from the National Institutes of Health (NIH) Research Infrastructure Programs (CFDA 93.351) is for the acquisition of a 700 MHz NMR spectrometer with a cryogenically cooled probe. The new state-of-the-art instrument will replace the nearly 20-year-old console and cryoprobe in the University of Pittsburgh's Department of Structural Biology NMR facility. This high-sensitivity spectrometer will enable reliable acquisition of high-quality spectra for...
The University of Pittsburgh was awarded a $650,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences under the Biological Sciences federal grant program (CFDA 47.074) to study transcriptional regulation of CRB and MPP5 genes in nuclear space. Specifically, the award will fund research examining how differential transcription of genes related to cell polarization and patterning are spatially coordinated in the nuclei of zebrafish retinal cells. The...
The University of Pittsburgh received a $537,317 Project Grant award from the National Science Foundation Division of Chemistry under the Mathematical and Physical Sciences federal grant program (CFDA 47.049). The grant supports the development of activity-based probes for genome-modifying enzymes through an interdisciplinary research project led by Dr. Kabirul Islam. The project aims to uncover novel DNA-modifying enzymes that protect and control genetic information through organic chemistry,...
This $776,309 federal Project Grant award from the National Science Foundation's (NSF) Biological Sciences Program (CFDA 47.074) will support research conducted by The Pennsylvania State University (Penn State) to explore the structural responses of intrinsically disordered proteins to chemical modifications that regulate gene expression. The research will use advanced nuclear magnetic resonance (NMR) spectroscopy techniques to investigate how phosphorylation and methylation of RNA polymerase II...
This National Science Foundation (NSF) Project Grant, awarded under the Biological Sciences program (CFDA 47.074), provides $154,000 in funding to Boston University from July 1, 2024 to June 30, 2027 to conduct research on protein aggregation and liquid-liquid phase separation (LLPS). The project, a collaborative effort between US and French researchers, aims to elucidate how protein-rich droplets can promote the pathological aggregation of proteins associated with neurodegenerative diseases,...
The National Science Foundation awarded a $276,000 Project Grant to the University of Pittsburgh under the Biological Sciences federal grant program (CFDA 47.074) to support a Postdoctoral Fellowship in Biology from June 1, 2022 to May 31, 2024. The Fellowship will fund integrative research investigating the rules of life governing interactions between genomes, environments and phenotypes. Specifically, the Fellow will conduct molecular evolution research on how adaptation to predatory amoeba,...
The University of Pittsburgh was awarded a $601,418 Project Grant from the National Science Foundation under the Biological Sciences federal grant program (CFDA 47.074) for the period of March 1, 2021 through February 28, 2025. The grant funds the REU SITE: Training and Experimentation in Computational Biology (TECBio) project. As the program description notes, the Biological Sciences program aims to promote progress in the biological sciences and strengthen the nation's scientific enterprise...