This NSF Biological Sciences (CFDA 47.074) award to Harvard University for $251,118 provides funding from October 1, 2024 to September 30, 2028 to conduct collaborative research on the shared genetic and cellular mechanisms of vertebrate limb and fin regeneration. The research will use a multi-layered comparative approach across salamanders, lungfish, and bichir fish to identify the key elements needed for limb and fin regeneration. Specific aims include: 1) testing if rapid activation of the...
The National Science Foundation (NSF) awarded a $426,255 project grant under the Biological Sciences program (CFDA 47.074) to the University of Texas at Austin to investigate the evolution of immune system development across amphibian life stages. The key objectives are to: (1) use mathematical models and empirical data to predict how evolutionary history, pathogens, and environment influence T cell diversity within and among frog life stages; (2) quantify T cell receptor diversity across...
This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $224,648 to the University of California, Irvine to conduct collaborative research on the shared genetic and cellular mechanisms underlying vertebrate limb and fin regeneration. The research aims to identify the core components of a "toolkit" for limb and fin regeneration by studying the axolotl, African lungfish, and grey bichir. Key objectives include: 1) Testing the...
The National Science Foundation (NSF) awarded a $494,261 Project Grant under the Biological Sciences program (CFDA 47.074) to the University of North Carolina at Chapel Hill (UNC-CH) to conduct research on frog skin evolution and adaptations. The project aims to: 1) quantify how frog skin has evolved over the past 200 million years in response to abiotic and biotic factors, 2) experimentally test the ability of anuran skin to decouple respiration and water loss, and 3) incorporate...
This Project Grant award from the National Science Foundation (NSF) Biological Sciences Program (CFDA 47.074) is funding collaborative research led by Vanderbilt University to investigate how amphibian immune systems develop and adapt across life stages. The $274,765 project aims to: (1) use mathematical models and empirical data to understand how evolutionary history, pathogens, and environment influence T cell receptor diversity in frogs over ecological and evolutionary timescales; (2)...
This $355,123 federal Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research to genetically modify the immune system of the African clawed frog (Xenopus tropicalis) to improve its resistance to the deadly chytrid fungus. The goal is to identify how altering the frog's major histocompatibility complex (MHC) genes affects its ability to fight off this pathogen and survive infection. The project includes a sub-award to the University...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program Project Grant award of $823,077 to George Washington University will support research on the evolutionary biomechanics and functional morphology of salamander locomotion. The 5-year project (July 1, 2024 - June 30, 2029) will integrate physiology, engineering, and evolutionary biology to examine how habitat preference and developmental strategy affect the structure and function of salamander limb bones and...
This $1,174,440.00 federal Project Grant award, funded by the National Science Foundation (NSF) Division of Integrative Organismal Systems (CFDA 47.074 Biological Sciences), supports collaborative research to identify the shared genetic and cellular mechanisms underlying vertebrate limb and fin regeneration. The research team at Louisiana State University, the prime awardee, is using a comparative approach across three animal models - salamanders, lungfish, and Polypterus - to uncover the core...
The National Science Foundation awarded a $240,000 Project Grant under the Biological Sciences program (CFDA 47.074) to support a postdoctoral research fellowship exploring the rules of life governing interactions between genomes, environments, and phenotypes. The fellowship will fund integrative research from November 1, 2023 to October 31, 2026 investigating how genetics, environments, and microbiomes contribute to emergent host phenotypes in green frog tadpoles. Specifically, the fellow...
This Project Grant award, funded by the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074), supports research on how the hormone aldosterone regulates amphibian metamorphosis from aquatic to terrestrial forms. The $629,995 award to the University of Cincinnati, with a performance period from September 2024 to August 2027, aims to reveal aldosterone's precise role in frog development by measuring corticosteroid levels, comparing wild-type and mutant tadpoles,...