The Department of Agriculture's National Institute of Food and Agriculture awarded a $649,916 Project Grant to Oregon State University under the Biotechnology Risk Assessment Research (BRAG) program (CFDA 10.219). The grant supports research to develop improved tools for excising transgenes used in genetic engineering, particularly for plants like forest trees that are difficult to genetically modify and have high ecological impacts. The research will: 1) create novel recombinase target sites resistant to DNA methylation to enhance transgene excision efficiency; 2) test various demethylation methods to improve recombinase activity; and 3) assess the local, genomic, and phenotypic impacts of the most effective methylation control systems. This work aims to enhance genome engineering capabilities for biosafety applications and inform regulators on the tradeoffs of using recombinases for transgene removal. The grant period of performance is July 1, 2023 to June 30, 2026.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $649.9k | 6/1/23 |