The National Institute of Food and Agriculture (NIFA) within the U.S. Department of Agriculture awarded a $790,000 Project Grant to the University of Illinois under the Agriculture and Food Research Initiative (AFRI) competitive grants program (CFDA 10.310). The four-year project aims to develop novel drug therapies to treat Cryptosporidium parvum infections in livestock. C. parvum is a parasite that causes serious diarrheal illness in calves, lambs, and goat kids worldwide. Currently, there are no effective drugs or vaccines available. The project will focus on developing small molecule inhibitors that block the parasite's glucose breakdown pathway, stopping its growth. Previous research has shown this approach can prevent disease in mouse models. The University of Illinois will work to identify lead chemical compounds suitable for new, safe, and effective anti-C. parvum drugs to improve animal health and productivity. A subaward of $100,000 was provided to Marshall B. Ketchum University to collaborate on targeting unique glycolytic enzymes of the parasite. The project is expected to yield drug candidates upon completion at the end of 2026.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $790.0k | 11/10/21 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
18762S | Marshall B. Ketchum University | Project Grant 20226701536347 | $135.0k | 5/7/24 |