The University of Illinois is the recipient of a $649,991 Project Grant award from the U.S. Department of Agriculture's Agriculture and Food Research Initiative (CFDA 10.310) program. The award will fund research to investigate the role of the CD163 receptor in regulating inflammatory responses in pigs infected with porcine circovirus type 2D (PCV2D) and other important pig pathogens. Key objectives include: 1) Comparing gene expression profiles in macrophages from CD163 wild-type and knockout pigs, 2) Evaluating gene expression in CD163 wild-type and knockout macrophages during infection with PCV2D and other viruses, and 3) Constructing gene profiles of immune cell populations in wild-type and knockout pigs during PCV2D infection. The research aims to understand how the absence of CD163 influences inflammatory responses, with the goal of developing pigs better adapted to modern production challenges. The award period runs from January 1, 2025 to December 31, 2027.
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