Cooperative Agreement W911NF1920095

The University of California, Los Angeles will provide research services under a $2.3 million cooperative agreement award from the Defense Health Agency. The award is part of the Military Medical Research and Development program (CFDA 12.420), which supports biomedical research to improve military and public health care. Specifically, UCLA will investigate nutritional modulation of the gut microbiome to mitigate hypoxia-induced cognitive impairment over a four-year period ending March 2027....

The Defense Health Agency awarded a $6,319,054 Project Grant to Brigham & Women's Hospital Inc., a non-profit hospital and research institution in Boston, MA, under the Military Medical Research and Development program (CFDA 12.420). The grant funds research to design microbiome-based therapies to prevent and ameliorate post-traumatic stress disorder (PTSD). The project involves collaboration with sub-awardees including Harvard University, the Forsyth Institute, and McLean Hospital. Key...

This federal Project Grant award, provided by the Department of the Army Medical Command under the Military Medical Research and Development program (CFDA 12.420), supports research on the impact of the gut microbiota on gut sensory neurocircuits in autism spectrum disorder. The $757,521 award was granted to Oregon State University, a prominent public land-grant research university, to conduct this advanced biomedical research over a period of 3 years, from July 1, 2025 to June 30, 2028. The...

The University of Alabama at Birmingham will develop a gut microbiome-based prognostic signature to predict the risk of hepatocellular cancer recurrence after ablative therapies under a $1.96 million Project Grant from the Department of the Army Medical Command. The grant is funded through the Military Medical Research and Development program (CFDA 12.420), which supports biomedical research that transforms military and public health care through innovative medical solutions for battlefield...

This $1,000,000.00 federal Project Grant award was provided by the Defense Health Agency under the Military Medical Research and Development (CFDA 12.420) program. The grant supports advanced biomedical research focused on investigating whether the gut microbiome coordinates with the gut-brain axis to contribute to behavioral alterations and cognitive injuries following traumatic brain injury (TBI), and if these effects are more profound in individuals with the APOE E4 genetic variant. The prime...

The National Institute of Mental Health (NIMH) awarded a $464,750 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to President and Fellows of Harvard College, also known as Harvard University. The purpose of this 2-year project, titled "GUT MICROBIOME CONTRIBUTIONS TO HUMAN EPISODIC MEMORY AND THE ROLE OF EARLY LIFE STRESS," is to identify the relationship between human gut microbiome composition, episodic memory performance, and the impact of early life...

This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $825,135 supports research to examine the relationship between gut microbiome-related metabolites, cerebrovascular small vessel disease, and cognitive impairment. The award, granted to The General Hospital Corporation (doing business as Massachusetts General Hospital), aims to: Investigate the association between gut microbiome metabolites and cerebrovascular small vessel disease...

This $630,905 project grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) will explore the role of the gut microbiome-derived metabolite imidazole propionate (IMP) in the progression of Alzheimer's disease (AD) and related dementias (ADRD). The project will characterize the relationship between IMP, blood-brain barrier disruption, and AD pathology in mouse models. It will also leverage existing data to determine the association between IMP, fluid AD biomarkers, and...

Biomesense Inc. received a $883,212 Project Grant award from the National Institutes of Health's National Center for Advancing Translational Sciences to develop a novel biosensor to accelerate investigations of the gut microbiome. The grant will support validating the microbial lysis and DNA isolation functions of a prototype biosensor over a 6-month period ending December 31, 2021. The biosensor is intended to enable dense, time-longitudinal sampling of participants' gut microbiomes in their...

This $325,139 federal Project Grant award, funded by the National Center for Advancing Translational Sciences (NCATS), 93.350 program, aims to examine the feasibility of using target-specific polyclonal antibodies to neutralize bioactive molecules in the gut microbiome. The primary goals are to 1) determine the impact of six proteins identified as overabundant in inflammatory gut disorders, and 2) evaluate the ability of immunoglobulin Y (IgY) antibodies to neutralize the physiological impacts...