Cooperative Agreement W81XWH1220107

This $369,806 Project Grant from the National Institutes of Health's National Institute on Deafness and Other Communication Disorders will fund research into objective screening tests for noise-induced hearing damage. The University of Wisconsin-Madison will investigate short- and long-term changes in cochlear, afferent, and efferent auditory system function due to noise exposure using otoacoustic emission-based assays of the middle ear muscle reflex and medial olivocochlear reflex....

This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $275,737 to Rewire Neuroscience LLC to develop and validate a machine learning platform for predicting the ototoxic potential of pharmaceutical compounds. The key objectives are to: 1) optimize and apply an innovative machine learning model that can categorize drugs as ototoxic or...

Auricle, Inc. received a $305,995 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), effective September 1, 2025, through August 31, 2026. The award supports development of a novel in-home neuromodulatory medical device designed to treat the underlying cause of tinnitus by addressing dysregulated neural synchrony, the root pathological mechanism of the...

The Department of Defense's Military Medical Research and Development program (CFDA 12.420) awarded a $358,245 Project Grant to the Massachusetts Eye And Ear Infirmary on May 15, 2024 for the project "IN SILICO SCREEN AND IN VIVO EVALUATION OF FDA-APPROVED DRUGS TO TREAT NOISE-INDUCED HEARING LOSS". The grant supports a two-year effort to screen FDA-approved drugs and evaluate the most promising compounds for their ability to protect against noise-induced hearing loss in cell...

The federal Project Grant award of $581,105.00 from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders (CFDA 93.173) program, supports research to develop natural-based therapies for sensory disorders, particularly aminoglycoside-induced hearing loss. The primary awardee, Creighton University, will 1) design and test piperlongumine derivatives with improved properties for targeting the TRPV1 channel, 2)...

Federal Grant Award Summary Restorear Devices LLC received a $307,962 Project Grant from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), awarded June 17, 2025, with completion targeted for June 30, 2026. The project develops and tests a non-invasive, non-pharmaceutical therapeutic intervention for tinnitus management using mild therapeutic hypothermia (MTH) delivered via the...

VDF Industries Inc., in collaboration with the University of California, San Francisco (UCSF), received a $915,591 Phase I Small Business Technology Transfer (STTR) Project Grant awarded on April 15, 2025, by the National Institute on Deafness and Other Communication Disorders under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The project aims to develop and validate Phonocath, a novel endovascular microcatheter device designed to objectively diagnose...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $2,433,859 supports research at The Johns Hopkins University to investigate age-related hearing loss and cognitive decline. The key objectives are to study the molecular, cellular, and connectivity changes in the central auditory system during normal aging and Alzheimer's disease, with the goal of developing targeted therapeutic strategies. The research integrates single-cell sequencing,...

The Department of the Army Medical Command awarded Case Western Reserve University a $402,500 Project Grant under the Military Medical Research and Development program (CFDA 12.420) to support the repurposing of a therapeutic candidate to mitigate synaptopathy and associated hearing loss. The two-year award, beginning September 1, 2021, will fund research activities at Case Western Reserve University and its affiliated University Hospitals of Cleveland location in Cleveland, Ohio to...

Federal Project Grant Award Summary Massachusetts Eye and Ear Infirmary received a $473,749 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), with an award date of September 11, 2025, and completion date of August 31, 2027. The grant supports an in silico screening and in vivo evaluation initiative to repurpose FDA (Food and Drug Administration)-approved...