This $131,408 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), will support research at the Massachusetts Eye and Ear Infirmary to investigate the impact of noise-induced hearing loss on neural activity in the auditory cortex and amygdala. The research plan includes three specific aims: 1) using two-photon calcium imaging to track changes in distinct...
The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded The Leland Stanford Junior University a $713,170 Project Grant under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The grant supports the development and validation of a Multimodality Micro-Optical Coherence Tomography (MM-MOCT) imaging technology to visualize the microscopic cellular structure and metabolic activity of the human inner ear. This new capability aims to...
This $656,723 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) will fund research by Northwestern University to advance the clinical use of distortion product otoacoustic emissions (DPOAEs) for hearing loss diagnosis and monitoring. The key objectives are to: 1) validate a new DPOAE protocol for improved detection of mild-to-moderate hearing loss, 2)...
The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded the University of Southern California (USC) a $456,500 Project Grant (CFDA 93.173) to develop a novel diagnostic test for sensory hearing loss. The "Gain-Sensitive Cochlear Microphonics" (GCM) test aims to assess the functional state and site of damage within the cochlear amplifier, which is crucial for hearing sensitivity and range. The proposed research will validate the GCM test in mice by comparing...
The U.S. National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a 5-year, $673,048 Project Grant (CFDA 93.173) to Case Western Reserve University to investigate the role of mitochondrial calcium regulation in acquired hearing loss. The research aims to determine the effects of acoustic overstimulation on cochlear hair cell function and morphology, and evaluate whether preventing mitochondrial calcium overload can protect against hearing deficits in mouse models. A...
The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a 5-year, $589,393 Project Grant (CFDA 93.173 - Research Related to Deafness and Communication Disorders) to Northwestern University to investigate the development of the neural circuit in the mammalian cochlea. The project aims to elucidate how the specialized mechanosensory cells (inner and outer hair cells) and their neural innervation assemble during development by genetically manipulating key...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $589,483 to Wayne State University to assess in vivo changes in central neuronal activation, molecular indicators of synaptic transmission, and motor function in response to vestibular nerve hypofunction generated by noise exposure. The project aims to evaluate the contributions of...
This Project Grant award of $623,777 from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), supports research on the role of the immune system and inflammation in hearing loss. The primary awardee, The Washington University, will conduct studies to examine how viral infections like cytomegalovirus (CMV) impact the development of the blood-labyrinth barrier in the inner ear and...
This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) will support research on the genetic causes of adult-onset hearing loss. The $676,533 award to the University of Pennsylvania aims to elucidate the role of the ZNF175/ZFP719 gene in pathogenic mechanisms leading to hearing loss, including investigating its effects on auditory synapses, ion...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $2,433,859 supports research at The Johns Hopkins University to investigate age-related hearing loss and cognitive decline. The key objectives are to study the molecular, cellular, and connectivity changes in the central auditory system during normal aging and Alzheimer's disease, with the goal of developing targeted therapeutic strategies. The research integrates single-cell sequencing,...
This $369,806 Project Grant from the National Institutes of Health's National Institute on Deafness and Other Communication Disorders will fund research into objective screening tests for noise-induced hearing damage. The University of Wisconsin-Madison will investigate short- and long-term changes in cochlear, afferent, and efferent auditory system function due to noise exposure using otoacoustic emission-based assays of the middle ear muscle reflex and medial olivocochlear reflex. Researchers aim to determine if combining these reflex metrics can distinguish noise exposure effects from aging effects. They will also evaluate relationships between cochlear, afferent, and efferent measures for short- and long-term noise exposures. Findings may support development of rapid screening tests and statistical models to enable early detection and prediction of noise-induced hearing loss. This research aligns with the Research Related to Deafness and Communication Disorders program's goals of investigating solutions to hearing-related problems.