This Project Grant award of $260,000.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support research to explore the basic molecular mechanism underlying skin blistering caused by exposure to chemical weapons. The University of Chicago, the awardee, will employ an integrative approach to investigate how skin vesicants, such as phenylarsine oxide and nitrogen...
This Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) will provide $937,468 to Northwestern University to understand the pathological mechanisms of sulfur mustard gas keratopathy (MGK) in the cornea. The research aims to explore how corneal mustard exposure induces autophagy, a cellular process that can play detrimental roles, via liberating the protein Beclin1 from the Beclin1-Bcl2 complex. The project will conduct in vitro and in...
This federal Project Grant award, provided by the National Institutes of Health (NIH) under the Biomedical Research and Research Training Program (CFDA 93.859), aims to advance the understanding of how Langerhans cells (LCs) and sensory neurons interact to regulate wound healing, itch, and pain following burn injuries. The University of Miami is the primary awardee, receiving $330,025 over the period of Sep 15, 2024 to Jul 31, 2028. The key objectives of this research project are to: 1)...
This $299,993 Project Grant awarded by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) supports the development of CMTX Biotech's drug candidate Incyclinide (CMT-3/COL-3) as a medical countermeasure for sulfur mustard-induced lung injury. The key objectives are to: Demonstrate a dose-dependent survival benefit of Incyclinide in a rat model of sulfur mustard inhalation exposure, with daily treatment beginning 24 hours post-exposure. Evaluate...
This federal Project Grant award, funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), aims to develop a novel therapeutic approach to improve angiogenesis and wound healing by delivering apoptotic neutrophils within a degradable hydrogel scaffold. The $172,700 award, effective August 20, 2024 through July 31, 2026, supports research to investigate the effects of the hydrogel-apoptotic neutrophil delivery on macrophage angiogenic signaling and its impact...
This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $317,239 to the University of Texas Medical Branch at Galveston (UTMB) to investigate conserved inflammatory mechanisms of vesicant-induced skin injury. The research aims to map the distribution of transcriptional pathways and biomediators associated with localized damage from exposure to sulfur mustard and lewisite vesicants using...
This Project Grant award from the National Institutes of Health's Trans-NIH Research Support program (CFDA 93.310) will provide $482,242 to The Medical College of Wisconsin, Inc. to conduct research on the mechanisms of mustard gas toxicity in the retina using a minipig model. The project aims to characterize the in vivo clinical, structural, and functional changes in the retina of a minipig model exposed to mustard gas, and identify molecular targets involved in retinal degenerative...
This $589,071 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) is funding research to investigate the immune mechanisms driving chronic ocular damage after acute exposure to nitrogen mustard, a potent chemical warfare agent. The key objectives are to: (1) determine how the acute innate corneal response to mustard exposure activates a persistent pathogenic T-helper 17 (Th17) immune response, and...
This Project Grant award, made by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of Dermisphere, an advanced dermal regeneration scaffold product by Fesariustherapeutics Inc. The $349,345 award aims to demonstrate the feasibility of using Dermisphere to manage acute major burn wounds. Preliminary studies have shown that Dermisphere can support rapid and sustained cellular...
This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $961,980 to the University of Illinois to investigate the role of cell senescence in the development of mustard gas keratopathy (MGK). The project aims to 1) examine the contribution of senescence and inflammatory secretions to the progression of corneal disease after acute exposure to nitrogen mustard, and 2) study the role of senescence in a new model of...