The National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program has awarded a $330,025 project grant (R01GM155523) to the University of Miami Office of Research Administration - School of Medicine Division to study the role of Langerhans cells in wound healing, itch, and pain following burn injuries. The 4-year project (September 15, 2024 - July 31, 2028) aims to advance the understanding of how Langerhans cells interact with sensory neurons to regulate wound healing and wound-related symptoms like itch and pain. The research will utilize optogenetic and chemogenetic techniques to selectively manipulate Langerhans cell activity and assess the impact on burn wound recovery and associated sensory phenomena. This work is expected to provide new insights into the molecular mechanisms behind post-burn wound healing, itch, and pain, and potentially offer innovative treatment approaches targeting specific Langerhans cell subsets.
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