Nexus: network for exposomics in the U.S.

Active Cooperative Agreement Awarded Last action

Award ID
U24ES036819
Recipient
Awarding agency
Obligated
$1,244,981

Award facts

Completion date 43% complete
Funding agency
National Insititue of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health, Department of Health and Human Services
Place of performance
New York, NY 10032, USA

Award details come from USAspending.gov.

Description

Abstract
The network for exposomics in the U.S. Or nexus is designed to advance the science of exposomics. Our team is focused on operationalizing the exposome by advancing measurement and modeling technologies and applying them to human health outcomes. We propose to coordinate current and future NIH-funded efforts on exposomics, and will strive to transform the entire biomedical and public health enterprise by inculcating the importance of comprehensive and systematic analysis of the environmental drivers of health and disease. We are confident that through our highly interconnected and globally distributed nexus team, we can drive this innovation and recalibrate the historically imbalanced gene x environment equation. We hypothesize that the nexus team can operationalize and embed exposomics throughout the entire biomedical enterprise to advance precision environmental health, which will be achieved through the following specific aims: aim 1. To provide outstanding organizational support and enable stakeholder engagement through the establishment of the administrative and stakeholder engagement hub. Aim 2. To establish a framework for exposomics analysis of biological and environmental samples through the formation of the chembio analytical sciences hub. Aim 3: to develop a framework for geospatial-based exposomics studies of environmental and social influences on health and disease including a scalable geospatial data science and research infrastructure via the formation of the geospatial sciences hub. Aim 4: to create a comprehensive exposomics digital framework to support precision environmental health via the formation of the nexus data sciences hub. We will support a dynamic community of practice, develop the constellation and beliefs inherent in a given scientific discipline, and advance our understanding of the environmental drivers of health and disease. Moreover, this project will establish the standard for exposomics profiling that integrates digital, biological, and geospatial markers to make exposome- wide association studies (exwas) a reality for studies of all human diseases establishing the paradigm for how we study the environment and human disease and providing the environmental complement to genomics that wild envisioned in 2005.

Transactions

Action Obligated Date
Amendment $100,000
Amendment $1,044,981
Original award $100,000

Subawards

Subrecipient Amount Awarded
The Johns Hopkins University JHU will serves as the subgrantee for this center grant. This designation is because this center proposal was conceirved and designed by DR garry miller. The… $65,500
Emory University Emory University will continue supporting NEXUS. Under Dr. Carmen Marsit, Drs. Marsit, Douglas Walker, Dean Jones, Xin Hu, and their teams will participate as… $55,284
The Regents Of The University Of California. San Francisco The Regents of the University of California, San Francisco will continue supporting NEXUS through the Data Core. Dr. Marina Sirota will serve as Co-Director… $111,734
Yale Univ Yale University will continue supporting NEXUS. Dr. Krystal Pollitt’s team will assess the chemical space covered by current and emerging technologies in… $107,299
President And Fellows Of Harvard College President and Fellows of Harvard College on behalf of Harvard Medical School will continue supporting the NEXUS Exposomics Digital Framework and Initiative.… $251,045
University Of Southern California University of Southern California will continue supporting NEXUS. Dr. Rima Habre will contribute to overall Center leadership with Drs. Gary Miller and Chirag… $117,897
University Of North Carolina At Chapel Hill University of North Carolina at Chapel Hill will continue supporting “NEXUS: Network for Exposomics in the U.S.” through the Geospatial Science Hub. Dr. Arcot… $144,201
President And Fellows Of Harvard College President and Fellows of Harvard College will support “NEXUS: Network for Exposomics in the U.S.” Harvard will develop the NEXUS Exposomics Digital Framework… $251,045
Yale Univ Yale University will support NEXUS. Dr. Krystal Pollitt’s team will conduct a trial to assess the chemical space covered by current and emerging technologies in… $107,299
The Regents Of The University Of California. San Francisco The Regents of the University of California, San Francisco will support NEXUS through the Data Core. Dr. Marina Sirota will co-direct the Data Core with Dr.… $111,700
University Of Southern California Dr. Habre will contribute to the NEXUS Center’s vision, aims, and goals in her role as Center MPI with Drs. Gary Miller and Chirag Patel and in her… $117,897
Emory University This subcontract, under the direction of Dr. Carmen Marsit, will allow for participation of Drs. Marsit, Walker, Jones, and Hu and their teams as needed in… $23,473
University Of North Carolina At Chapel Hill University of North Carolina at Chapel Hill will support NEXUS through the Geospatial Science Hub. Dr. Arcot Rajasekar will co-lead the hub and help develop… $167,526
Show all 13

Quick answers

Who received award U24ES036819?

U24ES036819 was awarded to The Trustees Of Columbia University In The City Of New York by National Institute of Environmental Health Sciences (National Institutes of Health) on September 4, 2024.

How much is award U24ES036819 worth?

$1,244,981 has been obligated on U24ES036819.

Which agency awarded U24ES036819?

National Institute of Environmental Health Sciences (National Institutes of Health) awarded U24ES036819, with funding from National Insititue of Arthritis and Musculoskeletal and Skin Diseases (National Institutes of Health).

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