Sickle cell disease pain analgesia and integrative network

Active Cooperative Agreement Awarded Last action

Award ID
U24AT012868
Recipient
Awarding agency
Obligated
$2,818,245

Award facts

Completion date 43% complete
Place of performance
Orange, CA 92868, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Our goal is to build sickle cell disease pain analgesia and integrative network (scdpain) as an innovative, dynamic and interactive platform that will advance the nccih's bold mission for research on pain mechanisms in sickle cell disease (SCD). Pain is one of the major comorbidities of SCD leading to poor quality of life, frequent opioid use and reduced survival. Compared to most other painful conditions, pain in SCD is unique because of the unpredictable and recurrent episodes of acute pain due to vaso-occlusive crises, in addition to chronic pain which continuously affects the majority of individuals. Pain in SCD can start during infancy and continue throughout life. Guided by an unmet need to address the morbidity associated with pain in SCD, our network is committed to profoundly impacting the science of sickle cell pain through leading expertise in pain, SCD pathobiology, end-organ damage and integrative interventions, assisted by cutting-edge technological advancement through 3 specific aims: [#1] "science without borders." to develop a collaborative network of multidisciplinary scientists, clinicians, analysts, and community partners to advance the understanding of SCD pain mechanisms; [#2] "promoting the future" for innovative, technically advanced, multidimensional, multidisciplinary and holistic team science approaches; and [#3] "hub to health," multimodal dissemination efforts to maximize access to scdpain. To achieve these goals, we will establish 6 focused working groups on, priority areas, pilot funding, sabbatical review, network foresight and review, annual review, and promotion of diversity and equity. We propose 3 critical priority areas, [i] to determine the central mechanisms involved in the persistence of pain and opioid use in SCD, [II] study "interoception of sickle pain perception" and/or improve SCD pain responses in the brain and other organs within animals and humans, and [III] examine chronic and acute pain and downstream complications and treatment side-effects requiring whole-person approaches. Finally, we will maximize access to scdpain via multimodal dissemination efforts to propel scientific advancements in SCD. The MPI team has extensive experience in propelling SCD pain research forward, bringing multidisciplinary teams together, and mentoring the next generation of pain scientists. In addition, a team of 9 collaborators bring extensive, diverse and cutting-edge technology which will lead research into a new ERA of mechanism-based translational understanding of sickle cell pain. Their passion for successful mentoring and promoting diversity is poised to provide a continuum of success to the network. The impact of scdpain will be monumental in: [1] building multidisciplinary research capacity to fulfill critical unmet needs of SCD pain; [2] incentivizing novel initiatives through pilot funds leading to r-series, heal and related grants and [3] catalyzing the future generation of scientists to accelerate SCD pain research. Scdpain will lead to a transformative framework and excite experts and novice researchers for mechanism- based, whole-person understanding of SCD pain mechanisms.

Transactions

Action Obligated Date
Amendment $924,408
Amendment $0
Amendment $0
Amendment Sickle cell disease pain analgesia and integrative network - our goal is to build sickle cell disease pain analgesia and integrative network (scdpain) as an… $929,890
Original award $963,947

Subawards

Subrecipient Amount Awarded
University Of Pittsburgh - Of The Commonwealth System Of Higher Education Our goal is to build Sickle Cell Disease Pain Analgesia and Integrative Network (SCDPAIN) as an innovative, dynamic and interactive platform that will advance… $0
University Of Illinois To fix dates. $0
University Of Texas At Dallas This pilot project will investigate the neural pathways that convey pain signals from the intestinal tract. Specifically, we will use chemogenetic approaches to… $50,000
University Of Pittsburgh - Of The Commonwealth System Of Higher Education Our goal is to build Sickle Cell Disease Pain Analgesia and Integrative Network (SCDPAIN) as an innovative, dynamic and interactive platform that will advance… $50,000
University Of Illinois Specific Aim. Determine whether the A) genetic and B) pharmacological inhibition of GABARAP to alleviate chronic pain and nephropathy in SCD. Chronic pain and… $50,000
Cincinnati Univ Of Project Title Mechanisms of musculoskeletal pain in sickle cell disease Principal Investigator Dr. Jahnavi Gollamudi Department of Internal Medicine/ University… $50,000
The Johns Hopkins University Dr. Claudia Campbell has leading expertise in clinical psychology, catastrophizing and individual disparities, with experience in sickle cell disease (SCD)… $65,662
Virginia Commonwealth University Task: Wally R Smith, MD will serve as MPI, and Cecelia Valrie PhD will serve as a Co-I on the U24 grant prepared to apply for RFA-AT-24-001 with a network… $37,779
University Of Texas Health Science Center At Houston The objective for this project is to screen and validate Hv1 inhibitors from plant extracts and botanical compounds as pain killer. Two main experiments on drug… $87,087
Virginia Commonwealth University Deliverables: Working in collaboration with Dr. Kalpna Gupta and Dr. Richard Harris, both at UCI, and with Dr. Claudia Campbell and Dr. Patrick Carroll, both at… $37,491
Case Western Reserve University This proposal seeks to establish a NEW collaborative network: Effective Network to advance Scientific Evidence related to Mechanisms of music-Based… $50,110
Emory University This proposal seeks to establish a NEW collaborative network: Effective Network to advance Scientific Evidence related to Mechanisms of music-Based… $62,379
The Johns Hopkins University Deliverable: By working together with MPIs Kalpna Gupta and William R Smith and others, Drs. Claudia Campbell, Patrick Carroll and the Johns Hopkins team of… $64,499
Show all 13

Quick answers

Who received award U24AT012868?

U24AT012868 was awarded to University Of California Irvine by National Center for Complementary and Integrative Health (National Institutes of Health) on September 5, 2024.

How much is award U24AT012868 worth?

$2,818,245 has been obligated on U24AT012868.

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