Cooperative Agreement U01FD006751

This SBIR Phase II Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $1,219,222 to Nirrin Technologies Inc. to continue development of their tunable laser spectrometry system for rapid analysis of biopharmaceutical formulations. The goal is to optimize the design, fabricate 6 beta systems, and prepare them for external validation testing with major biopharmaceutical companies....

The National Institute of General Medical Sciences (NIGMS) awarded a $302,417 Project Grant to Physical Sciences Inc. (PSI) under CFDA 93.859 Biomedical Research and Research Training program. The purpose of this award is to develop a novel in-line biomanufacturing process analytical technology tool that enables real-time monitoring of biomolecules in large-scale bioreactors for gene therapy and vaccine manufacturing. The technology combines Raman scattering and autofluorescence spectroscopy...

Zaiput Flow Technologies LLC received a $275,000 Project Grant award from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop an innovative, continuous crystallization device for pharmaceutical manufacturing. The goal is to improve the purification process of active pharmaceutical ingredients, which is a critical step used in over 90% of pharmaceutical production. The novel device aims to address scalability, cost, and...

The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $170,678 Project Grant (R21EB036615) to the University of Cincinnati for the development and in-vivo testing of continuous sensors for monitoring large analytes such as insulin, NT-proBNP, IL-6, and albumin. The objective is to create aptamer-based sensors with unprecedented sensitivity to enable continuous monitoring of large proteins and peptides, which has previously been a significant technological challenge....

Partillion Bioscience Corp. was awarded a $659,037 Project Grant from the National Institutes of Health's National Institute of General Medical Sciences to develop reagent products enabling high-throughput screening and selection of single cells based on secreted bio-products. Under the Biomedical Research and Research Training program (CFDA 93.859), Partillion plans to transition its lab-on-a-particle technology—highlighted as a 2020 SLAS Innovation Award winner—into the first reagent product...

The National Science Foundation awarded Opera Bioscience, Inc. $275,000 under the Technology, Innovation, and Partnerships program (CFDA 47.084) to develop a low-cost bacterial production platform for manufacturing high purity recombinant proteins and growth factors. The award period runs from June 15, 2023 through May 31, 2024. Opera Bioscience will utilize this funding to demonstrate the ability of its innovative protein production platform to solve challenges in traditionally costly and...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 to Avanpore LLC, a for-profit limited liability company, will develop a novel membrane separation technology to enable energy-efficient separation and recovery of small molecules from industrial process streams. The project aims to create functionalized nanoporous membranes from commercial polymers to address the limited solvent and thermal resistance of existing...

The federal Project Grant award R44GM154572 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to support the development and scale-up of Chromatan Inc.'s Continuous Countercurrent Tangential Chromatography (CCTC) platform for recombinant adeno-associated virus (rAAV) vector purification. The $5,037,617 award aims to commercialize the CCTC system, which promises to reduce downstream production costs...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award for $275,000 will support the development of a plasmonic nanopore sensor device for quality control of adeno-associated viruses (AAVs) used in gene therapy. The proposed device will enable accurate characterization of AAV payload (single-stranded DNA, double-stranded DNA, or empty) at low, pre-scale-up concentrations to optimize formulations. The project aims to demonstrate the...

This $174,769 National Science Foundation Project Grant supports the acquisition of a high-pressure stopped-flow spectrophotometer/fluorimeter system at Rensselaer Polytechnic Institute. The instrument, the first of its kind in the U.S., will be housed in RPI's Analytical Biochemistry Core Facility to study biological systems under extreme conditions. It will enable research on the effects of high hydrostatic pressure on biological macromolecules and enzyme kinetics, furthering understanding...