Cooperative Agreement U01DD001116

The University of Kansas Medical Center Research Institute, Inc. was awarded a $2,368,728 Cooperative Agreement grant by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The primary goal of this 5-year project titled "Motor Outcomes to Validate Evaluations in Pediatric FSHD (MOVE PEDS)" is to validate clinical outcome assessments and...

This $429,000 award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to investigate therapeutic strategies for rescuing metabolic deficiencies in spinal and bulbar muscular atrophy (SBMA). The project will leverage two SBMA mouse models to evaluate whether systemic administration of nicotinamide mononucleotide (NMN) can bypass deficiencies in the muscle...

This $438,365 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to investigate the role of the CD38 protein and its potential as a therapeutic target for Spinal and Bulbar Muscular Atrophy (SBMA). The key products and services to be delivered include using stem cell technology and CRISPR-corrected isogenic controls to examine...

This federal Project Grant award from the National Center for Advancing Translational Sciences (CFDA 93.350) will support a $450,836 research project at the University of California, San Diego (UCSD) to develop and validate a Computational Motor Objective Rater (CMOR) system for quantifying motor symptoms in patients with blepharospasm, a form of focal dystonia. The key objectives are to: 1) Evaluate the CMOR system's convergent validity with patient-reported severity of facial spasms and...

This Cooperative Agreement award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $196,420 to the Ohio State University Wexner Medical Center to implement the R25 Neurological Surgery Resident Research Training Program. The program aims to provide research training to neurosurgery residents in basic, translational, and clinical sciences to support...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $272,000.00 to support a Clinical Trials Methodology Course in Neurological Disorders (CTMC). The goal of this training program is to supply the healthcare system with effective clinical researchers and biostatisticians capable of implementing well-designed clinical...

This $1,472,597 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports cutting-edge research on myotonic dystrophy types 1 and 2 (DM1 and DM2) at the University of Florida and the University of Rochester. The key products and services to be delivered include: Developing and characterizing new mouse models for DM2 to accelerate preclinical...

This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders (CFDA 93.173) program, provides $620,240 to the Massachusetts Eye and Ear Infirmary to conduct an observational study examining vestibular pathophysiology and clinical outcomes in patients with sporadic vestibular schwannomas (SVS) and neurofibromatosis type 2-related schwannomatosis (NF2/VS). The key objectives are to:...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $225,000 project grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to Louisiana State University Health Sciences Center New Orleans to conduct research on how mutations in the PPP2R5C and PPP2R5D genes, which encode regulatory subunits of the PP2A phosphatase complex, affect synaptic development, neural activity, learning, and memory. The project aims to generate and...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program to The Johns Hopkins University. The $245,625 award, which runs from August 7, 2024 to June 30, 2026, will fund the "DELTA ECMO ABI STUDY" to investigate the causes of acute brain injury in patients receiving extracorporeal membrane oxygenation (ECMO) therapy. The research...