This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) totaling $225,000 will fund research to study how mutations in genes related to the PP2A phosphatase complex affect synaptic development, neural activity, learning, and memory. The award recipient, Louisiana State University Health Sciences Center New Orleans, will generate and analyze fly transgenes that mimic human intellectual disability-linked mutations in the PPP2R5C and PPP2R5D genes. This research aims to establish a fly model to elucidate the molecular mechanisms underlying B56-dependent cognitive dysfunctions, with the potential to inform future therapeutic approaches for treating intellectual disability and other neurological conditions.
Generated 3/25/25, 3:31 AM