This Cooperative Agreement award from the National Cancer Institute (NCI), under the Cancer Treatment Research program (CFDA 93.395), provides $440,171 to the Fred Hutchinson Cancer Center in Seattle, WA to systematically investigate and mitigate the impact of pre-analytical variables on the accuracy and reliability of targeted, multiple reaction monitoring mass spectrometry (MRM-MS)-based immune protein measurements in cerebrospinal fluid (CSF) from pediatric brain tumor patients participating in clinical trials. The key goals are to: (I) identify and characterize sources of CSF biospecimen pre-analytical variation affecting MRM-based assay performance for quantifying immunomodulatory protein biomarkers in CSF, (II) develop, validate, and disseminate a pre-analytical quality control standard operating protocol (SOP) to counteract pre-analytical variation impact on the performance of MRM assays quantifying immunomodulatory proteins in CSF, and (III) validate the biospecimen SOP through real-world testing by analyzing prospectively collected clinical trial samples at two CLIA labs to demonstrate harmonization. The award period runs from Mar 19, 2025 to Feb 28, 2030.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $440.2k | 3/19/25 |