This federal Project Grant award, totaling $440,287.00, was provided by the National Cancer Institute (NCI) under their Cancer Detection and Diagnosis Research program (CFDA 93.394). The objective is to establish a simplified and accessible procedure for the simultaneous extraction of DNA, RNA, and protein from tumor touch imprints, which could democratize biobanking for lower-resource institutes. The proposed approach leverages tumor touch imprints on glass slides, combined with a multi-analyte molecular extraction protocol, to enable genomic, gene expression, and protein analysis from smaller tumor samples. Key project goals include optimizing the extraction protocol, demonstrating non-inferiority to fresh-frozen tissue, and minimizing pre-analytical variables related to sample storage and preparation. If successful, this approach could broaden options for biomarker discovery and enable correlative analysis of multiple analytes from a single small tumor sample.
Generated 3/25/25, 5:33 AM