This Project Grant award from the National Cancer Institute (CFDA 93.396 Cancer Biology Research) to Vanderbilt University provides $335,944 from September 1, 2024 to August 31, 2027 to further develop, refine, and validate the university's proprietary free-solution assay (FSA) technology and compensated interferometric reader (CIR) platform. The FSA-CIR system represents a novel, label-free, solution-phase, ultra-sensitive, and enzyme-free technology that can quantify molecular interactions across a wide range of biological matrices. This paradigm-shifting approach aims to address critical gaps in current cancer research tools by enabling studies on unmodified targets and probes, full-length membrane protein interactions, allosteric modulation, and weak protein-protein interactions. The technology is also expected to accelerate quantitative assay development, address biomarker discovery and validation challenges, and support ex-vivo measurements to guide first-in-human dose determinations. By providing a versatile, highly sensitive, and matrix-compatible platform, this project seeks to advance fundamental cancer biology research and improve early detection, diagnosis, and treatment development.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $335.9k | 8/19/24 |