Cooperative Agreement U01CA294507

The National Cancer Institute (NCI) has awarded a $1,128,990 Cooperative Agreement to the Dana-Farber Cancer Institute (DFCI) under the 21st Century Cures Act - Beau Biden Cancer Moonshot program (CFDA 93.353). The funding will support DFCI's efforts to construct a "Myeloma Multidimensional Precancer Atlas" to map the spatial and genomic evolution of precursor conditions to multiple myeloma, a blood cancer, across a racially diverse patient population. The project aims to identify the key molecular and microenvironmental changes that drive the transition from healthy cells to overt multiple myeloma. By leveraging DFCI's extensive biospecimen collection and well-annotated longitudinal clinical data, the researchers will use cutting-edge spatial transcriptomics, single-cell genomics, and imaging mass cytometry techniques to create a comprehensive atlas of disease progression over the five-year project period.