The National Cancer Institute (NCI) awarded a 5-year, $1,063,411 Cooperative Agreement under the 21st Century Cures Act - Beau Biden Cancer Moonshot (CFDA 93.353) program to Vanderbilt University. This funding will support the construction of a three-dimensional (3D) multimodal molecular atlas of colorectal cancer (CRC) across different ages of onset. The atlas will utilize cutting-edge technologies, such as spatial transcriptomics, multiplexed immunofluorescence microscopy, and imaging mass spectrometry, to comprehensively characterize CRC tissue and map the transitions from precancerous to cancerous components within the same tumor. The goal is to provide unprecedented insights into the genetic, transcriptomic, metabolomic, microbial, and architectural features of CRC across age groups to better understand the molecular differences between early-onset and later-onset CRC. As a sub-awardee, Vanderbilt University Medical Center will contribute its expertise in CRC pathogenesis, surgical sample collection and processing, and immunohistochemical staining.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $1.1m | 8/21/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
OSA00000460S | Vanderbilt University Medical Center | Cooperative Agreement U01CA294527 | $178.3k | 10/24/24 |