Cooperative Agreement U01AG089242

Award Date 8/15/24
Completion Date 7/31/28
Dollars Obligated $1.1M
Federal Grant Program
93.866
Assistance Type
Cooperative Agreement
Place of Performance
San Antonio, TX 78229, USA
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The University of Texas Southwestern Medical Center received a $618,401 Cooperative Agreement award from the National Institute on Aging (CFDA 93.866 - Aging Research) to characterize the pharmacokinetics (PK) and pharmacodynamics (PD) of mTOR inhibitors, such as sirolimus and everolimus, in older adults. The primary goal is to precisely estimate fundamental PK/PD parameters of these drugs in older adults without confounding illnesses. This research will validate measurement techniques, quantify...
This $640,068 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to study the impact of the drug everolimus on chronic inflammation in aging through an ancillary study (IMTOR) to the NIA-funded EVERLAST trial. The IMTOR study will focus on analyzing the effects of everolimus on immune cell function, particularly CD4+ T cells, to determine how the drug can reduce age-related inflammation and improve healthspan. The project will involve...
The National Institute on Aging (NIA) awarded a Project Grant (CFDA 93.866, Aging Research) to Texas A&M AgriLife Research to conduct the "Test of Rapamycin in Aging Dogs (TRIAD)" clinical trial. The $2,015,762 award, effective December 1, 2024 through November 30, 2029, will support a randomized, double-blind, placebo-controlled veterinary trial to determine if weekly rapamycin treatment can increase lifespan and healthspan in 580 companion dogs. The study will also assess the...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,414,024 to The University of Texas Health Science Center at San Antonio to study the role of paracrine growth factor signaling in thymus function and age-associated dysfunction. The research aims to independently manipulate FGF21, mTOR, and autophagy pathways to understand their regulatory relationships and effects on cortical thymic epithelial cell (cTEC) size, morphology, and overall thymus...
This is a Cooperative Agreement award from the National Institute on Aging (NIA), under the federal Aging Research grant program (CFDA 93.866), totaling $1,001,704 with a project period from August 2024 to July 2029. The award is to The Trustees of the University of Pennsylvania to conduct research aimed at developing and standardizing methods for analyzing nicotinamide adenine dinucleotide (NAD) and its metabolites in blood, serum, urine, and tissues. The key objectives are to: 1) establish...
This $1,020,661 Cooperative Agreement award, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), aims to develop and validate standardized methods for measuring NAD+ and related metabolites in human samples. The key products and services to be delivered include: Optimizing and validating sample collection and storage protocols to preserve the integrity of NAD+, NADH, NADP, and NADPH metabolites. Finalizing validation of an advanced liquid chromatography-tandem mass...
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