Project Grant R44MH096650

This Project Grant award from the National Heart Lung and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $343,203 to Cyion Technologies LLC to develop a novel in vitro electrophysiology system for high-throughput measurement of intracellular action potential (IAP) in human-derived cardiomyocytes. The system leverages a 3D nanoelectrode array (NEA) technology to enable scalable recordings of IAP signals from many individual cardiomyocytes. This...

Cornell University received a $100,000 Project Grant award from the National Science Foundation's Technology, Innovation, and Partnerships program to develop a cell-free biosensing platform integrating transmembrane proteins. The award period is from July 1, 2022 to December 31, 2022. Specifically, the university will utilize recent advances in biotechnology and bioelectronics to establish a process for rapidly assembling customized transmembrane proteins into a biomimetic sensing device without...

The National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a 3-year, $450,000 Project Grant to The Washington University to develop a novel "Plasmon-Enhanced Expansion Fluorospot" (PEEFS) technology. This bioplasmonic imaging method combines fluorescent nanoparticles and expansion microscopy to enable highly sensitive and high-resolution monitoring of cell-secreted proteins at the single-cell level. Key project objectives...

The University of California, San Diego (UCSD) has been awarded a $802,003 Cooperative Agreement under the National Institute of Neurological Disorders and Stroke's (NINDS) 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative. The project, titled "Optimization of Transparent Microelectrode Arrays for Large-Scale Multimodal Monitoring of Neural Activity," aims to develop a novel "Neuro-Clear" probe technology that...

The National Institute of Child Health and Human Development (NICHD) awarded a $312,817 Project Grant (CFDA 93.865: Child Health and Human Development Extramural Research) to Giner Inc., a small business research and development firm in Auburndale, Massachusetts, to develop a point-of-care testing (POCT) instrument for highly sensitive and near-real-time perinatal monitoring of oxytocin levels. The instrument will utilize an electrochemical assay to enable measurement of oxytocin with a limit of...

The National Institute of Mental Health (NIMH) awarded a $1,897,078 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Spikegadgets, Inc., a San Francisco-based company that specializes in manufacturing precision research tools for neuroscience. The goal of this 2-year project, awarded on July 16, 2024, is to provide a commercial ecosystem for multi-electrode array (MEA) manufacturers to scale their products to many more electrodes than they currently offer. The key...

The National Science Foundation (NSF) awarded a $300,000 Project Grant under its Biological Sciences program (CFDA 47.074) to the Georgia TECH Research Corporation for the "TOOLS4CELLS: EAGER: A MOLECULAR PURSUIT FOR THE ENGRAM: MICROFLUIDIC TEMPORAL TRANSCRIPTOMICS FOR SINGLE CELL LEARNING" project. This 2-year effort aims to develop innovative microfluidic tools and workflows to investigate the role of non-coding RNA in learning and memory storage in single-celled organisms. Key...

This National Science Foundation (NSF) Biological Sciences grant award provides $2,225,964 to the Georgia Tech Research Corporation (Georgia Tech) to develop a novel biosensing platform called "protocell communities" that can be used for rapid, low-cost medical diagnostics. The project aims to create a tool that can diagnose medical conditions by detecting and integrating multiple indicator molecules, addressing limitations of single-analyte diagnostics. The protocell technology uses...

This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) will fund the development of a novel "Electrified Cryo-EM" (ecryo-EM) technique at the University of California, Los Angeles (UCLA). The ecryo-EM approach aims to capture the structural changes in neurons during an action potential, providing unprecedented insights into the molecular mechanisms underlying electrical signaling in the...

This $275,000 project grant from the National Science Foundation's Engineering Directorate (CFDA 47.041) will fund the development of novel electronic-photonic silicon carbide neural probes for recording and stimulating neural activity. The Georgia Tech Research Corporation will receive funding on behalf of collaborating researchers to design penetrating neural probes made entirely of silicon carbide, a robust material proven to withstand the corrosive brain environment long-term. The probes...