Project Grant R44FD005669

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $434,950 to The Research Foundation For The State University Of New York to develop a microfluidic device that models the complex structure and selective filtration function of the kidney's glomerulus and Bowman's capsule. This "Glomerular-Bowman's Capsule System on a Chip" will...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $312,088 to Sojourn Medtech LLC to develop the CANSIM simulator. The CANSIM is a smart, personalized, and dialysis-specific training device to teach critical cannulation skills to dialysis nurses and patient care technicians. The key features include: 1) dialysis-specific design, 2) realistic and low-maintenance...

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $238,184 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to the University of Delaware to develop an easy-to-use 3D microphysiological system (MPS) that can spatially pattern the extracellular matrix, stromal cells, and soluble factors to recapitulate the developing nephron. The goal is to provide researchers without MPS expertise a tool to investigate the role and...

The National Institutes of Health Office of the Director awarded the University of Southern California a $2.9 million project grant under the Trans-NIH Research Support program (CFDA 93.310) to develop a synthetic kidney as a revolutionary solution to the shortage of kidneys available for transplantation. The three-year project will generate a transplantable synthetic kidney using stem cell and bioengineering technologies, then evaluate its growth, differentiation, vascularization and functional...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK - CFDA 93.847) to Biomedinnovations, Inc. (BMI Organbank) will fund the development of a platform for extended kidney preservation via subnormothermic perfusion. The $3,740,270 award, effective September 20, 2024 through June 30, 2026, aims to optimize BMI's perfusion device and perfusate, evaluate the impact of warm ischemic injury and preservation duration, and compare the function of...

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $299,999 Project Grant (CFDA 93.847) to Hibar Microsciences, LLC to develop a prototype for CLEAR, a novel hemodialysis cartridge designed to improve the clearance of protein-bound uremic toxins (PBUTs) from the blood of patients with end-stage renal disease. The key objectives are to: 1) Develop a method for immobilizing lipocalin proteins onto dialysis membrane matrices to enhance PBUT removal; 2) Create and...

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $350,000 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to Katharos, Inc., a for-profit woman-owned business, to develop a novel extracorporeal device for improving phosphate removal in hemodialysis patients. The project aims to create a standalone phosphate adsorption device that can be integrated with conventional hemodialysis to enhance phosphate removal and...

This Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program provides $550,000 to develop a remote monitoring system to reduce morbidity and mortality associated with infections among patients undergoing peritoneal dialysis (PD). The project aims to create a medical device that can enable real-time, continuous, and quantitative monitoring of numerous biomarkers relevant to PD-associated infections. This technology...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $238,943 to Duke University to develop an automated platform for accurately tracking urine output in hospitalized heart failure patients. The key objectives are to: 1) validate the accuracy and timeliness of the device in measuring urine volume compared to conventional methods; 2) quantify the reduction in time lag between patient urination...

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $704,672 Phase I Small Business Innovation Research (SBIR) grant under CFDA 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research) to Flowpoint Medical Inc. in Overland Park, Kansas. The grant supports the development of an implantable, self-sealing needle guide system to improve vascular access and safety for hemodialysis patients. The project aims to refine the manufacturability and...