Cooperative Agreement R01CA155348

This $233,250 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports a 2-year study to establish the feasibility and reproducibility of advanced hyperpolarized 13C pyruvate MRI imaging of the human brain on a major clinical MRI platform (Siemens). The study aims to first test the technique in vitro using a human-scale 3D-printed phantom model, then evaluate the reproducibility of in vivo hyperpolarized 13C pyruvate brain imaging in a cohort of...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), is supporting the development and translation of hyperpolarized 13C-pyruvate MRI techniques to assess cardiac metabolic remodeling in heart disease. The $807,225 award to the University of California, San Francisco aims to: 1) Develop hyperpolarized MRI methods to measure metabolic flexibility and glucose oxidation-glycolysis coupling;...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to evaluate the feasibility of using novel imaging techniques to assess mitochondrial function and availability in an Alzheimer's disease (AD) model. The $456,394 award to The General Hospital Corporation (doing business as Massachusetts General Hospital) will fund the exploration of two methods: 1) using [18F]BCPP-EF PET to image the availability of mitochondrial complex-I, which is...

This three-year, $3.15 million Project Grant from the National Institutes of Health's National Institute on Aging will support the development and optimization of genetically encoded fluorescent redox indicators to image oxidative stress in Alzheimer's disease mouse models. Leveraging the complementary expertise of investigators at the University of Virginia in fluorescent indicators and fluorescence imaging of redox signaling as well as metabolic drivers in Alzheimer's, the researchers will...

This $400,000 Project Grant awarded by the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) aims to develop a multifunctional electron paramagnetic resonance imaging (EPRI) instrument that can simultaneously acquire maps of tissue oxygen pressure (pO2) and pH. The key objectives are to: 1) develop a 25 mT Halbach-type permanent magnet, 2) create new multi-modal transmit-receive electronics based on field programmable gate array (FPGA) technology, and 3) build...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides USD 306,530 to Spinhance LLC to develop and evaluate a novel, MRI-compatible medical device for continuous administration of the gaseous contrast agent hyperpolarized xenon-129 (HPX). The device is designed to synchronize HPX delivery with patient breathing patterns and other physiological measures, enabling dynamic imaging of...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $762,960 to the University of Texas at Austin to develop small single-fluorescent protein biosensors that can accurately measure the concentrations and fluctuations of metabolic intermediates involved in cellular signaling pathways. The goal is to understand how the availability and regulation of these signaling...

The National Institute on Aging (NIA) awarded a $196,525 Project Grant (CFDA 93.866 - Aging Research) to Georgia Tech Research Corporation to investigate spatial and temporal heterogeneity in mitochondria during aging using advanced in vivo high-content chemical imaging techniques. The research aims to unravel the relationship between mitochondrial dynamics, physiological homeostasis, and age-related conditions within living animal models. The project will leverage Broadband Coherent...

The National Cancer Institute (NCI), under the Cancer Detection and Diagnosis Research program (CFDA 93.394), awarded a $400,000 Project Grant to O2M Technologies LLC to improve the image acquisition speed of their Single Point Imaging (SPI) oxygen mapping technology. SPI is a subset of the company's Pulse Electron Paramagnetic Resonance Imaging (PEPRI) method, which can generate high-resolution 3D partial oxygen pressure (pO2) maps in live tissues and tumors. The goal of this project is to...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), aims to investigate the potential of hyperpolarized 13C magnetic resonance spectroscopic imaging (HP 13C MRSI) and ultra-short echo time magnetization transfer (UTE-MT) imaging to non-invasively study the role of lactate metabolism and remyelination in two multiple sclerosis (MS) mouse...