Cooperative Agreement D25AC00460
- Federal Cooperative Agreement Award Summary The University of California, San Diego received a $18.33 million Cooperative Agreement from the Advanced Research Projects Agency for Health (ARPA-H, CFDA 93.384) awarded September 25, 2025, with completion targeted for September 24, 2028. The project aims to develop a scalable, patient-specific bioprinted liver using induced pluripotent stem cells (iPSCs) tailored to individual patient anatomy and physiology without requiring donor tissue or...
- Federal Cooperative Agreement Summary Harvard College, through its Office for Sponsored Programs Division, received a $17.8 million Cooperative Agreement from the Advanced Research Projects Agency for Health (ARPA-H, CFDA 93.384) on September 26, 2025, to develop an off-the-shelf engineered liver tissue product to address the critical shortage of donor organs for liver transplantation. The primary objective is to create a universal, transplant-ready graft utilizing next-generation technologies...
- Federal Cooperative Agreement Summary The University of Texas Southwestern Medical Center received a $14.33 million Cooperative Agreement awarded September 10, 2025, under the Advanced Research Projects Agency for Health (ARPA-H) program (CFDA 93.384) to develop a Vascularized Immunocompetent Tissue as an Alternative Liver (VITAL). The three-year project, concluding September 9, 2028, focuses on creating a functional bioengineered liver organ suitable for orthotopic transplantation. Technical...
- Federal Cooperative Agreement Summary Wake Forest University Health Sciences received a $13.43 million Cooperative Agreement award from the Advanced Research Projects Agency for Health (ARPA-H, CFDA 93.384) on September 26, 2025, with a completion date of September 25, 2028. The award supports the development of bioprinted vascularized autologous renal tissue constructs designed to augment kidney function in patients with kidney disease and address the nation's organ donor shortage. The Wake...
- Federal Cooperative Agreement Summary Award Details: Funding Agency: National Institutes of Health (NIH) Office of the Director Federal Grant Program: Trans-NIH Research Support (CFDA 93.310) Awardee: University of Pittsburgh – Of the Commonwealth System of Higher Education Total Funding Obligated: $556,457.00 Award Date: April 8, 2026 Project Completion Date: March 31, 2031 Place of Performance: Pittsburgh, PA 15222 Products and Services: The University of Pittsburgh will develop a fully...
- Federal Grant Award Summary Carnegie Mellon University received a $383,029 Project Grant from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420), awarded on September 30, 2025, with a completion date of September 29, 2028. The award funds development of a novel digital twin technology designed to optimize normothermic vascularized composite allograft (VCA) preservation. This research leverages Carnegie Mellon's demonstrated expertise in...
- Federal Cooperative Agreement Summary The University of Texas MD Anderson Cancer Center received a $3.41 million Cooperative Agreement from the Advanced Research Projects Agency for Health (ARPA-H, CFDA 93.384) awarded on August 20, 2025, with an anticipated completion date of August 19, 2027. This award funds the CyberHealthIntelligence project, which develops an artificial intelligence-driven cybersecurity system for healthcare infrastructure by extending the Department of Energy-funded Common...
- Federal Cooperative Agreement Summary The Advanced Research Projects Agency for Health (ARPA-H, CFDA 93.384) awarded The Cleveland Clinic Foundation a $2.73 million Cooperative Agreement on August 20, 2025, to develop noninvasive wearable technology for continuous cardiac output monitoring in congenital heart disease (CHD) patients. The primary deliverable is a battery-operated, flexible ultrathin "eTattoo" device capable of daily absolute cardiac output measurement at home, addressing...
- Federal Grant Award Summary Carnegie Mellon University received a $272,947 project grant from the Department of the Army Research Development and Engineering Command (RDECOM) under the Basic Scientific Research program (CFDA 12.431) on May 1, 2026, with an ultimate completion date of April 30, 2028. This new start Defense University Research Instrumentation Program (DURIP) award funds research on automated bioink generation and high degree-of-freedom, multi-material bioprinting technologies...
- Federal Cooperative Agreement Summary The Salk Institute for Biological Studies received a $7.62 million Cooperative Agreement from the Advanced Research Projects Agency for Health (ARPA-H, CFDA 93.384) awarded on February 23, 2026, with completion targeted for August 22, 2027. The project develops a sonogenetic platform technology designed to overcome limitations of conventional drug-based treatments by minimizing off-target effects and systemic side effects through a novel, scalable...
Award Details: Carnegie Mellon University received an $18.05 million Cooperative Agreement from the Advanced Research Projects Agency for Health (ARPA-H, CFDA 93.384) on September 26, 2025, with completion scheduled for September 25, 2028. The award funds the Liver Immunocompetent Volumetric Engineering (LIVE) project, a collaborative research initiative to develop three-dimensional bioprinted liver tissue constructs capable of addressing the critical shortage of donor organs and eliminating the need for systemic immunosuppression in transplant recipients. Products and Services: The LIVE project delivers advanced bioprinted liver tissue engineered through collaborative research combining 3D bioprinting technology, liver tissue engineering, stem cell biology, and clinical expertise from major transplant centers. Carnegie Mellon leads the initiative with sub-awardees including the University of Pittsburgh, University of Washington, Fluidform Bio Inc., Mayo Clinic, and Charité – Universitätsmedizin Berlin. Specific deliverables include development of GMP-grade human induced pluripotent stem cell lines and derivative hepatocytes, endothelial cells, and hepatic stellate cells; implementation of standardized operating procedures for cell expansion, quality control, and cryopreservation; advancement of FRESH (freeform reversible embedding of suspended hydrogels) 3D printing technology for functional tissue construction; and preclinical testing of bioprinted liver constructs. These collaborative efforts aim to transform acute liver failure treatment and organ transplantation by creating personalized, immunocompetent liver tissue alternatives that address disparities in access to life-saving transplant therapies.Federal Cooperative Agreement Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $18.1m | 9/26/25 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
1047781503495S | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Cooperative Agreement D25AC00460 | $578.1k | 1/16/26 | |
1047781503536S | University Of Washington | Cooperative Agreement D25AC00460 | $2.0m | 12/22/25 | |
1047781504687S | Fluidform Bio, Inc. | Cooperative Agreement D25AC00460 | $134.4k | 12/22/25 | |
1047781504975S | Charité - Universitätsmedizin Berlin | Cooperative Agreement D25AC00460 | $630.6k | 12/15/25 | |
1047781503517S | Mayo Clinic | Cooperative Agreement D25AC00460 | $362.6k | 11/24/25 |