Cooperative Agreement D25AC00206
- This $449,598 federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) aims to develop a novel wireless, noninvasive optical e-tattoo capable of continuously and simultaneously monitoring arterial and venous oxygenation. The key innovations include: (1) an ultrathin, stretchable e-tattoo with an array of photoplethysmography sensors over major artery-vein pairs; (2) algorithms to separate arterial and venous pulses and convert absorbance data into...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $349,734 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Actiox LLC, a biomedical technology company in Thousand Oaks, California. The project aims to develop a wearable microneedle-based biosensor for continuous, real-time cardiac troponin I monitoring. The goal is to demonstrate the feasibility of this transformative biosensor technology to enable earlier detection of ischemic events and...
- This federal Project Grant award of $598,636, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports the development of the EMULAATE platform by Spheric Bio Inc. The EMULAATE technology aims to address the mismatch between standard left atrial appendage occlusion (LAAO) devices and patient anatomy by enabling the assembly of personalized, soft implants directly inside the patient's body through a minimally-invasive procedure. This could...
- This $500,000 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports the development of the Hemotago HATS-OFF (Hemotag Assessment for Short-Term Outcomes of Heart Failure) technology by Aventusoft LLC, a small disadvantaged business in Boca Raton, Florida. The HATS-OFF system provides a non-invasive, at-home method for long-term monitoring of heart failure patients to detect decompensation early and enable timely therapy...
- This $9,433,900 Cooperative Agreement awarded by the U.S. Department of the Interior's Interior Business Center under the Advanced Research Projects Agency for Health (ARPA-H) program (CFDA 93.384) funds the development of an innovative tissue scanning and cancer detection system called "Magic Scan" by Tulane University. The key objectives are to: (1) develop an ultra-high speed, high-resolution tissue scanner that can image over 450 sq. cm of surgical tissue at 250 nm resolution...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $295,153 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Safebeat RX Inc. The funding supports the development of a novel, smartwatch-enabled technology that allows patients with low-risk atrial fibrillation to safely initiate antiarrhythmic medications at home. The technology analyzes post-drug ECG data taken by patients using a machine learning algorithm and provides this information to...
- This $360,320 Project Grant awarded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) aims to develop and test the first continuous electrochemical sensors for monitoring large protein and peptide analytes, such as insulin and cardiac markers. The project, titled "Aptamer Tagging with Redox Quenchers: A Critical Breakthrough in the Sensitivity of...
- The National Heart, Lung, and Blood Institute, through the Cardiovascular Diseases Research federal grant program (CFDA 93.837), awarded $706,616 to the University of Texas at Arlington on June 1, 2025 to develop an "Elastic Exosome-Releasing Conductive Patches for Heart Repair". The project aims to create a fully degradable, elastic, and conductive cardiac patch that can promote heart function restoration and electrical integration with damaged cardiac tissue following a myocardial...
- The U.S. National Heart, Lung, and Blood Institute, through the Cardiovascular Diseases Research federal grant program (CFDA 93.837), awarded a $406,221 Project Grant to the Florida Institute of Technology Inc. (Florida TECH) on September 15, 2025. The grant supports the development of a novel, low-cost, machine learning-based and wearable technology for continuous monitoring of heart failure parameters, such as left ventricular function. The project aims to address the gap in remote cardiac...
- This federal Project Grant award of $362,250 was provided by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to evaluate the impact of treating elevated blood pressure in the inpatient setting on patient outcomes. The project, titled "Evaluating Whether Treating Elevated Blood Pressure in the Inpatient Setting Impacts Patient Outcomes: The ACT-BP Pilot," aims to obtain key knowledge needed to conduct a larger randomized clinical trial by...
The U.S. Department of Health and Human Services' Interior Business Center awarded a $2,732,120 Cooperative Agreement under the Advanced Research Projects Agency for Health (ARPA-H) program to The Cleveland Clinic Foundation. The purpose of the project is to develop a battery-operated, flexible, ultrathin, quad-modal wireless device "eTattoo" to provide at-home, ICU-level monitoring of cardiac output to prevent low cardiac output syndrome (LCOS), the leading cause of postoperative mortality in patients with congenital heart disease. This innovative, noninvasive technology aims to improve health outcomes and reduce mortality rates for both children and adults with congenital heart conditions requiring surgery. The 2-year project period runs from August 2025 through August 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.7m | 8/20/25 |