Cooperative Agreement D25AC00239
- This Cooperative Agreement award from the Center for Drug Evaluation and Research at the Food and Drug Administration (FDA) (CFDA 93.103 - FDA Research) provides $250,000 to the University of Pittsburgh to develop and qualify their "Liver Acinus Microphysiological Systems (LAMPS)" platform as a drug development tool. The objective is to use this platform to better understand drug absorption, distribution, metabolism, excretion, and toxicity (ADME-TOX) in both healthy and diseased liver...
- This Cooperative Agreement, awarded by the Department of the Interior's Interior Business Center under the Advanced Research Projects Agency for Health (ARPA-H) program (CFDA 93.384), provides $8,945,662.00 in funding to Emory University to develop a functional prototype system called "MARGINCALL" that can rapidly image surgical specimen contours, mark resection margins, and use AI to map cancer and assess tumor proximity to margins. The goal is to reduce current rates of lumpectomy...
- This is a $365,378 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), to The University of Texas Southwestern Medical Center. The grant, awarded on March 3, 2025 with a completion date of December 31, 2029, aims to investigate post-liver transplant (LT) recovery and outcomes beyond graft and patient survival. The project will characterize distinct LT...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), a component of the National Institutes of Health, awarded a $292,116 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Renovate Biosciences Inc. The grant aims to generate human livers from donor patient-specific cells using pigs as a "bio-incubator" for xenotransplantation, with the long-term goal of producing immune-compatible solid organs for...
- This $9,433,900 Cooperative Agreement awarded by the U.S. Department of the Interior's Interior Business Center under the Advanced Research Projects Agency for Health (ARPA-H) program (CFDA 93.384) funds the development of an innovative tissue scanning and cancer detection system called "Magic Scan" by Tulane University. The key objectives are to: (1) develop an ultra-high speed, high-resolution tissue scanner that can image over 450 sq. cm of surgical tissue at 250 nm resolution...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is focused on developing novel bioengineered regenerative medicine solutions based on vasculogenic regenerative medicine technology. The $543,826 award, granted on December 10, 2024, aims to investigate the mechanisms underlying in vivo vasculogenic reprogramming, specifically examining...
- This Cooperative Agreement award, with a total funding of $1,250,000.00 over a period from June 1, 2025 to May 31, 2027, was provided by the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program. The project aims to develop a novel platform technology for the scalable generation of high-quality, tumor-targeted induced naïve T cells for off-the-shelf anti-cancer immunotherapies. The key product to be delivered is a proprietary method to...
- This federal Project Grant award for $664,769.00, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is supporting research conducted by Oregon Health & Science University to develop allogeneic hepatocyte (liver cell) transplantation without the need for immunosuppression. The research aims to overcome key barriers to wider adoption of liver cell therapy,...
- This federal Project Grant award of $1,356,922.00 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports the development of novel hydrogel-coated electrospun (HES) biomaterials for replacement heart valves. The key objectives are to: Identify optimal biomaterial and leaflet geometry characteristics to develop replacement heart valves with greater durability, resistance to thrombosis, and improved hemodynamics. This will leverage the...
- This Project Grant award of $1,625,000 from the U.S. Department of Defense's Military Medical Research and Development program (CFDA 12.420) supports in-vivo mechanistic characterization of the angiogenic immune checkpoint in liver cancer at the Trustees of the University of Pennsylvania. The research aims to advance scientific understanding and develop solutions for this important health challenge. The award commenced on September 1, 2023 and is scheduled for completion by August 31, 2027. As a...
This Cooperative Agreement award, valued at $14,330,656.00 and funded by the Advanced Research Projects Agency for Health (ARPA-H) under CFDA 93.384, aims to develop a vascularized, immunocompetent liver tissue (VITAL) as an alternative to traditional liver transplantation. Key objectives include: The award will also generate a parametric algorithm to model branched organ vasculature. This 3-year project, starting in September 2025, brings together expertise from UTSW, UC Davis, and Penn State to advance this transformative liver tissue engineering solution.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $14.3m | 9/10/25 |