Cooperative Agreement 2349466

Award Date 7/15/25
Completion Date 6/30/27
Dollars Obligated $990K
Federal Grant Program
47.084
Assistance Type
Cooperative Agreement
Place of Performance
Research Triangle Park, Durham, NC, USA
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This Cooperative Agreement award from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program provides $990,477 in funding to Drive Therapeutics L.L.C. to optimize the manufacturing efficiency of bispecific aptamer therapeutics for treating retinal diseases such as wet age-related macular degeneration and diabetic macular edema.

The project aims to enhance the efficacy and reduce the treatment burden of these therapies compared to the current standard of care. Key activities include optimizing the conjugation of polyethylene glycol to the bispecific aptamer to improve its pharmacokinetic properties, evaluating the biophysical properties and inhibitory activity of the optimized bispecific aptamer, and assessing its in vivo performance in an animal model of retinal disease. The findings from this project are expected to advance scientific and technological understanding applicable to other disease targets and indications.

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