Cooperative Agreement 2325045
- This $274,990 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships) supports the development of a physics-based machine learning platform for predicting the crystal structure of small drug molecules. The technology aims to accelerate and reduce the cost of early-stage pharmaceutical research and development by computationally analyzing the crystal structure properties that determine key...
- This $1,000,000 cooperative agreement from the National Science Foundation (NSF) will fund the development of a blockchain ecosystem and artificial intelligence to optimize prior authorization processes in the pharmaceutical industry. Red Oak Strategic LLC will leverage distributed ledger technology to create an encrypted, decentralized patient data sharing network among prescribers, payers, and patients. Smart contracts will automate criteria fulfillment, facilitate machine learning-based...
- This $220,000 Project Grant award from the National Science Foundation (NSF) under the Computer and Information Science and Engineering (CISE) program supports the development of advanced computational methodologies for drug discovery and development. The primary awardee, the Regents of the University of Minnesota, will create a comprehensive generative AI framework capable of efficiently generating high-quality drug candidates with multiple desired properties. This initiative aims to expedite...
- This SBIR Phase II Cooperative Agreement, awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084), provides $1,213,322 in funding to Lavo Life Sciences Inc. to develop a physics-based machine learning platform for predicting the crystal structure of small drug molecules. The objective is to accelerate the development and commercialization of new pharmaceutical products by optimizing drug product formulations and solid forms....
- This STTR Phase I project, awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084), aims to revolutionize drug discovery by accelerating molecular dynamics simulations through advanced AI techniques. The $305,000 award, granted on July 15, 2025, with a completion date of June 30, 2026, will enable Giwotech Inc. to develop a robust neural network model capable of simulating protein systems up to 500 times faster than...
- The National Science Foundation (NSF) awarded a $2,375,361 Cooperative Agreement to Koliber Biosciences Inc. under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program. The project aims to develop computational tools that leverage artificial intelligence and machine learning to design improved protein "transporter" molecules. These transporter proteins control the movement of valuable chemicals in and out of cells, which is a critical limitation in microbial...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 to Om Therapeutics Inc. will support the development of a system to enable the rapid, scalable, and cost-effective discovery of new medicines using machine learning. The project aims to encapsulate proteins and small molecules in millions of miniaturized compartments to screen for interactions that could identify novel drug candidates. The key innovations include...
- This STTR Phase I Project Grant, awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, aims to develop a new analytical toolkit for optimizing and discovering combination drug therapies. The $284,736 award, effective March 1, 2025 through February 28, 2026, will enable the commercialization of the Multidimensional Synergies of Combination (MUSYC) algorithm. This algorithm leverages AI to analyze laboratory and clinical data...
- This $554,265 Project Grant award from the National Science Foundation (NSF) under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) aims to develop novel machine learning (ML) and computational approaches for computer-aided drug design (CADD). The project will introduce new mathematical representations of molecular geometries using Ricci curvatures and spectral graph analysis to improve the accuracy of target-ligand binding affinity prediction in virtual screening....
- The National Science Foundation (NSF) awarded a $1,454,200 Cooperative Agreement to Insilica LLC under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program. The project, titled "PROTO-OKN THEME 1: BIOBRICKS-OKG AN OPEN KNOWLEDGE GRAPH FOR CHEMINFORMATICS AND CHEMICAL SAFETY," aims to transform the open-source BioBricks system into an effective knowledge graph backend. This will facilitate access to crucial chemical health and safety data, enabling the use of AI in...
This $1,000,000 Cooperative Agreement award from the National Science Foundation's (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program aims to accelerate R&D in the pharmaceutical industry through the development of streamlined machine learning algorithms for small data applications in advanced manufacturing. The project, awarded to Sunthetics Inc., seeks to save time and resources by up to 95% in lead optimization and route scouting during pre-clinical drug development by employing machine learning to guide experimental design with small datasets. This solution is expected to grant patients quicker access to medicines and enable companies to generate earlier revenue and maintain longer market exclusivity. The project addresses the challenge of optimizing categorical variables, specifically solvent selection, in synthetic processes, which plays a vital role in chemical industry efficiency, cost reduction, and environmental friendliness. The award has an initial performance period from October 1, 2023, to September 30, 2025.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.0m | 9/20/23 |