Purchase of GMP grade crispr base-editing guide RNA for xscid patients at the clinical center. Synthego holdings LLC (ambis #2280586)

Active Purchase Order Awarded Last action

Contract number
75N98026P00112
Awardee
Awarding agency
Obligated
$140,000

Award facts

Contract value 100% obligated
$140,000.00 Current and potential, with all options
Completion date 61% complete
Current and potential, with all options
Funding agency
National Institute of Allergy and Infectious Diseases National Institutes of Health, Department of Health and Human Services
NAICS code
541714 Research and Development in Biotechnology (except Nanobiotechnology)
PSC
6505 Drugs And Biologicals
Set-aside
No set-aside
Competition
1 offer Only One Source
Pricing
Firm Fixed Price
Place of performance
North Bethesda, MD 20852, USA

Award details come from SAM.gov/FPDS.

About this award

The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $140,000 firm fixed-price purchase order to Synthego Holdings LLC for the procurement of GMP-grade CRISPR base-editing guide RNA intended for X-linked severe combined immunodeficiency (XSCID) patients at the NIH Clinical Center. The contract, awarded on March 11, 2026, with an ultimate completion date of March 10, 2027, represents a targeted procurement of specialized genetic engineering materials to support advanced therapeutic research and potential clinical applications. No set-aside designation was applied to this award.

The work will be performed in Rockville, Maryland, leveraging Synthego's expertise in manufacturing clinical-grade synthetic RNA molecules. XSCID is a severe genetic disorder affecting immune system development, and this procurement supports NIAID's mission to develop innovative treatments for immunological diseases. The GMP-grade specification indicates the guide RNA must meet pharmaceutical manufacturing standards suitable for human clinical use, reflecting the advanced nature of this gene-editing research initiative within the federal clinical research enterprise.

Quick answers

Who was awarded contract 75N98026P00112?

75N98026P00112 was awarded to Synthego Holdings LLC by Office of Logisitics and Acquisition Operations (National Institutes of Health) on March 11, 2026.

How much is contract 75N98026P00112 worth?

The government has obligated $140,000 on 75N98026P00112.

Which agency awarded contract 75N98026P00112?

Office of Logisitics and Acquisition Operations (National Institutes of Health) awarded 75N98026P00112, with funding from National Institute of Allergy and Infectious Diseases (National Institutes of Health).

Was contract 75N98026P00112 competed?

The government received 1 offer.

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