The National Science Foundation's Biosensing program is seeking applications for fundamental engineering research on devices and methods for measurement and quantification of biological analytes. Examples of biosensors include electrochemical/electrical, optical, plasmonic, paper-based, and nanopore-based biosensors. The program is particularly interested in proposals that address critical needs for biomedical research, public health, food safety, agriculture, forensics, environmental protection, and homeland security. Proposals incorporating emerging nanotechnology methods are especially encouraged. The evaluation criteria emphasize the novelty and/or potentially transformative nature of the proposed work, as well as its importance in terms of engineering science and potential impact on society and/or industry. Proposals must be submitted by the annual unsolicited proposal deadline. Typical awards range from $100,000 to $120,000 per year for single-institution projects, or up to $180,000 per year for multi-institution collaborations. The duration of unsolicited awards is generally one to three years. Proposals requesting substantially higher amounts must be discussed with the Program Director prior to submission.