The Cellular and Biochemical Engineering (CBE) program, part of the Engineering Biology and Health cluster at the National Science Foundation (NSF), is seeking proposals for fundamental engineering research that advances the understanding of cellular and biomolecular processes in engineering biology. The program supports research that leads to the development of enabling technology for advanced biomanufacturing in support of the therapeutic cells, biochemical, biopharmaceutical, and biotechnology industries. Key areas of interest include metabolic engineering, synthetic biology, quantitative systems biotechnology, cell culture technologies, protein and enzyme engineering, and the development of novel "omics" tools for biomanufacturing applications. Proposals should address the novelty and/or potentially transformative nature of the proposed work, as well as its importance in terms of engineering science and potential impact on society and/or industry. The typical award size for the program is around $100,000 per year, with allowance for up to $200,000 per year for collaborative projects or those involving multiple investigators. The duration of unsolicited awards is generally one to three years. Faculty Early Career Development (CAREER) program proposals are also strongly encouraged, with a five-year award duration.