Reimagining Protein Manufacturing (RPM)

The Defense Advanced Research Projects Agency seeks proposals through its Reimagining Protein Manufacturing program to develop technologies enabling immediate synthesis of bioactive protein medical countermeasures and production enzymes within 24 hours at a yield of at least 500 doses per week. Evaluation will assess advancement of production yield and time reduction as well as controlled addition of post-translational modifications to proteins through capability demonstrations at defined intervals. Proposals are due November 16, 2021 to address technical areas including increased production yield and time reduction as well as incorporation of post-translational modifications.

There is no set-aside designation for this opportunity. Multiple awards are anticipated for research conducted over a base period of 26 months and optional second period of 24 months. Key metrics include production of 500 doses per week within approximately 24 hours to establish foundational technologies for distributed, on-demand manufacturing of protein-based medical countermeasures and ensure timely Defense Department access to critical therapeutic proteins.