Intent to Sole Source - Untargeted Metabolomics Analysis
Closed Special Notice Posted
- Solicitation number
- NOI-OLAO-CC-26-008751
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Responses due
- Set-aside
- No set-aside
Opportunity facts
- NAICS code
- 541380 Testing Laboratories and Services
- PSC
- Q301 Reference Laboratory Testing
- Place of performance
- Bethesda, Maryland 20892, United States
Notice details come from SAM.gov. Updated .
About this opportunity
The National Institute of Health, Clinical Center (NIH-CC) announced on August 21, 2026 a Notice of Intent to sole-source a contract with Metabolon, Inc. for untargeted metabolomics analysis of human fecal samples, with a capability statement deadline of August 31, 2026. This is not a request for proposal; the agency intends to negotiate with Metabolon under the sole-source authority of 41 U.S.C. 253(c)(1) based on a determination that only one responsible source can satisfy agency requirements.
The Tissue Biophysics and Hemodynamics (TBHP) Branch seeks metabolomics analysis to support a collaborative protocol among the NIH Clinical Center, the National Institute of Diabetes and Digestive and Kidney Diseases, and the National Heart, Lung, and Blood Institute. The study will quantify and compare microbiome-derived metabolites and dietary xenobiotics in diets composed primarily of unprocessed versus ultra-processed food to investigate metabolic pathway alterations. The analytical work requires detection and quantification of small-molecule metabolites including dietary xenobiotics and microbiota-derived compounds in fecal samples, simultaneous analysis of cytokines and chemokines in minimal sample volumes, integration with Thermo Fisher Scientific Luminex platforms for downstream immune and metabolic biomarker analysis, and comprehensive untargeted metabolite coverage validated for human fecal samples.
Any responsible source capable of providing the required services may submit a capability statement by email to valerie.gregorio@nih.gov with subject line "NOI-CC-OLAO-26-008751" by 12:00 PM Eastern Standard Time on August 31, 2026. All responses received by the closing date will be considered.
Notice text
This is a Notice of Intent, not a request for proposal. The National Institute of Health, Clinical Center (NIH-CC) intends to negotiate on an other than full and open competition basis with the following vendor: Metabolon, Inc.
Acquisition Description:
The TBHP Branch (TBHP) requests the purchase of a contract for Metabolon, Inc., to perform untargeted metabolomics analysis of human fecal samples. The materials will be used in a collaborative protocol between the NIH Clinical Center TBHP Branch, the National Institute of Diabetes and Digestive and Kidney Diseases, and the National Heart, Lung, and Blood Institute to quantify and compare microbiome-derived metabolites and dietary xenobiotics in diets primarily consisting of unprocessed and ultra-processed food to investigate metabolic pathways altered by ultra-processed diets.
The metabolomics analysis needs to be able to:
- Detect and quantify a broad panel of small-molecule metabolites (including dietary xenobiotics and microbiota-derived compounds) in fecal samples
- Enable simultaneous analysis of a large array of cytokines, chemokines, and metabolites in small sample volumes
- Interface with Thermo Fisher Scientific Luminex platforms for downstream immune/metabolic biomarker analysis
- Provide comprehensive untargeted metabolite coverage validated for use with human fecal samples.
The statutory authority for this sole source requirement is 41 U.S.C. 253(c) (1) as implemented by FAR 6.302-1 only one responsible source and no other supply of service will satisfy agency requirements. THIS IS NOT A REQUEST FOR PROPOSAL. All responsible sources that could provide the required may submit a capability statement that will be considered by email (subject line to reference NOI-CC-OLAO-26-008751) by 12:00 PM eastern standard time on 08/31/2026 to: valerie.gregorio@nih.gov.
All responses received by the closing date of this synopsis will be considered by the Government. A determination not to compete this requirement, based upon responses to this notice, is solely within the discretion of the Government.
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