Crycooling unit CU/5

This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation number is RFQ-NICHD-19-109 and is issued as a Request for Quotation (RFQ). The solicitation /contract will include all applicable provisions and clauses in effect through Federal Acquisition Circular 2005-99. The North American Industry Classification (NAICS) Code is 334516 with a size standard of1000. This acquisition is being conducted using Simplified Acquisition Procedures in accordance with FAR Part 13. The National Institutes of Health (NIH), National Institute of Digestive, Diabetes & Kidney Diseases (NIDDK) has a requirement to procure on a sole source basis with Bruker BioSpin Corporation, 15 Fortune Drive, Billerica, MA 01821-3991 to procure a Cryocooling unit CU/5

Basic water-cooled CU/5 cryocooling unit, no He compressor requires water cooling provided by customer. Regular maintenance of the CryoPlatform is required since several major parts are subject to mechanical wear. Max. intervals are 10'000 operating hours or 2 years - whatever is earlier. The Natural Products Chemistry Section together with other members of the Laboratory of Bioorganic Chemistry, NIDDK, carry out research that involves the discovery and development of small molecule and protein inhibitors that can prevent bacterial or viral infections. Chemical structure elucidation is critical to this research. This precise structural elucidation is done with sophisticated Nuclear magnetic instruments (NMRs) Each NMR spectrometer comprises a superconducting magnet, a console that controls the generation, application and detection of radiofrequency pulses, and a probe that detects the NMR signal and transmits this to the console. In contrast to superconducting magnets which last effectively forever, technological improvements both in console and probe design significantly enhance capabilities and permit one to design ever more complex experiments that were not previously feasible. Our current 500 MHz NMR console was purchased in 2005 and has aged out. We are seeking to upgrade as it is no longer serviceable, and hence in need of upgrading. Further, the upgrades to the latest generation of consoles will increase attainable signal-to-noise by 20%, reduce spectrometer artefacts and facilitate
high quality data acquisition in samples where the solvent is predominantly H2O (as opposed to D2O). (Note most NMR data are acquired in H2O to permit observation of exchange backbone and sidechain amide groups). The cryoplatform replacements for Bruker spectrometer 500 MHz is required as the current unit is over 15 years old and are no longer serviceable. The cryoplatform is an integral component of the cryoprobes that involve cooling to liquid helium temperatures, thereby reducing thermal noise and affording increases of 3-5 fold in signal-to-noise. All our NMR spectrometers are being used to push the frontiers of NMR spectroscopy in structural biology, with considerable emphasis being placed on the application of these methods to AIDS related structural problems. These include work on HIV-1 Gag polyprotein, HIV-1 reverse transcriptase, the fusion and cytoplasmic domains of HIV-1 gp41, HIV-1 integrase, HIV-1 protease, and various host proteins that are relevant to the pathogenesis of AIDS. The following specifications are required: The upgrade module must be able to be installed directly into the existing instrument, the Bruker Ascend NMR spectrometer 500 MHz NMR. The Avance Console must be recognized and controlled by the software package that currently operates the Bruker Ascend NMR spectrometer.

Details:
Z159072 Cryocooling unit CU/5
Basic water cooled CU/5 cryocooling unit, no He compressor requires water cooling provided by customer. Regular maintenance of the CryoPlatform is required since several major parts are subject to mechanical wear. Max. intervals are 10'000 operating hours or 2 years - whatever is earlier. Such maintenance is not covered by the cryoprobe warranty and must be purchased separately [PN: BH0444].

Service to install Cryocooling unit CU/5

The offeror must include a completed copy of the following provisions: 1) FAR Clause 52.212-1 Instructions to Offerors - Commercial items; 2) FAR Clause 52.212-2, Evaluation - Commercial Items. As stated in FAR Clause 52.212-2 (a) The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation will be advantageous to the Government, price and other factors considered. The following factors will be used equally to evaluate offers: Technical Evaluation, Price, and Past Performance. The Government will make award based on Best Value.

Note: Past Performance Information: Vendors must submit a listing of the most recent contracts/awards (minimum of 3) which demonstrate similar work in nature to this Solicitation. Contracts/awards may include those entered with the Federal Government, state and local governments and commercial concerns. Include the following information for each contract or subcontract:

1. Name of Contracting Organization
2. Contract Number (for subcontracts provide the prime contract number and the subcontract number)
3. Contract Type
4. Total Contract Value
5. Description of Requirement
6. Contracting Officer's Name and Telephone Number
7. Program Manager's Name and Telephone Number

3) FAR Clause 52.212-3, Offeror Representations and Certifications - Commercial Items; 4) FAR Clause 52.212-4, Contract Terms and Conditions - Commercial Items; 5) FAR Clause 52-212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial Items - Deviation for Simplified Acquisitions. The Dun and Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN) and the certification of business size shall be included. The clauses are available in full text at http://www.arnet.gov/far.

Interested vendors capable of providing the Government with the items specified in this synopsis should submit their quotation to the below email address. Quotations will be due 11:00AM EST July 19, 2019. Offerors shall send the quotation/proposal to Verne Griffin at verne.griffin@nih.gov. The quotation must reference Solicitation number RFQ- RFQ-NICHD-19-109. All responsible sources may submit a quotation, which if timely received, shall be considered by the agency. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov."

Faxed copies will not be accepted.

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