Crycooling unit CU/5

THIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS TO AWARD A CONTRACT OR PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION.

The National Institutes of Health, National Institute of Child Health and Development (NICHD) intends to award a purchase order without providing for full and open competition to Bruker BioSpin Corporation, 15 Fortune Drive, Billerica, MA 01821-3991 to procure a Cryocooling unit CU/5.

Basic water-cooled CU/5 cryocooling unit, no He compressor requires water cooling provided by customer. Regular maintenance of the CryoPlatform is required since several major parts are subject to mechanical wear. Max. intervals are 10'000 operating hours or 2 years - whatever is earlier.

The Natural Products Chemistry Section together with other members of the Laboratory of Bioorganic Chemistry, NIDDK, carry out research that involves the discovery and development of small molecule and protein inhibitors that can prevent bacterial or viral infections. Chemical structure elucidation is critical to this research. This precise structural elucidation is done with sophisticated Nuclear magnetic instruments (NMRs) Each NMR spectrometer comprises a superconducting magnet, a console that controls the generation, application and detection of radiofrequency pulses, and a probe that detects the NMR signal and transmits this to the console. In contrast to superconducting magnets which last effectively forever, technological improvements both in console and probe design significantly enhance capabilities and permit one to design ever more complex experiments that were not previously feasible. Our current 500 MHz NMR console was purchased in 2005 and has aged out. We are seeking to upgrade as it is no longer serviceable, and hence in need of upgrading. Further, the upgrades to the latest generation of consoles will increase attainable signal-to-noise by 20%, reduce spectrometer artefacts and facilitate high quality data acquisition in samples where the solvent is predominantly H2O (as opposed to D2O). (Note most NMR data are acquired in H2O to permit observation of exchange backbone and sidechain amide groups). The cryoplatform replacements for Bruker spectrometer 500 MHz is required as the current unit is over 15 years old and are no longer serviceable. The cryoplatform is an integral component of the cryoprobes that involve cooling to liquid helium temperatures, thereby reducing thermal noise and affording increases of 3-5 fold in signal-to-noise. All our NMR spectrometers are being used to push the frontiers of NMR spectroscopy in structural biology, with considerable emphasis being placed on the application of these methods to AIDS related structural problems. These include work on HIV-1 Gag polyprotein, HIV-1 reverse transcriptase, the fusion and cytoplasmic domains of HIV-1 gp41, HIV-1 integrase, HIV-1 protease, and various host proteins that are relevant to the pathogenesis of AIDS.

The following specifications are required: The upgrade module must be able to be installed directly into the existing instrument, the Bruker Ascend NMR spectrometer 500 MHz NMR. The Avance Console must be recognized and controlled by the software package that currently operates the Bruker Ascend NMR spectrometer.

NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE
The intended procurement is classified under NAICS code 334516 of with a Size Standard of 1000.

REGULATORY AUTHORITY
The resultant contract will include all applicable provisions and clauses in effect through the Federal Acquisition Regulation (FAR) Circular (FAC) 2005-99 effective 19 Jan 2017. This acquisition is conducted under the procedures as prescribed in FAR subpart 13-Simplified Acquisition Procedures at an amount not exceeding the simplified acquisition threshold ($250,000) and FAR Subpart 12- Acquisition of Commercial Items.

STATUTORY AUTHORITY
This acquisition is conducted under the authority of 41 U.S.C. 253(c) under provisions of the statutory authority of FAR Subpart 6.302- FAR 6.302-1-Only one responsible source and no other supplies or services will satisfy agency requirements 41 U.S.C. 253(c)(1).

Place of Performance
National Institutes of Health
9000 Rockville Pike
Bethesda MD 20892
United States

CLOSING STATEMENT
This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: certification to provide OEM service and parts, unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov."

A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement.

All responses to this notice shall be submitted electronically by 11:00 AM Eastern Standard Time, on July 11, 2019 to verne.griffin@nih.gov and shall include solicitation #7NICHD-19-109 in the subject line.

Assessment of Capability
Technically Capability to provide required service with certification from the OEM.

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