A Repository of Mouse Models for Cytogenetic Disorders
Award Notice Posted
- Solicitation number
- NIH-NICHD-IDD-2015-7
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Awarded
- to Jackson Laboratory
- Set-aside
- No set-aside
Opportunity facts
- Contract number
- HHSN275201500004C Federal IDV award
- NAICS code
- 541711 Research and Development in Biotechnology
- PSC
- Not on record
Notice details come from SAM.gov. Updated .
Notice text
4 versions
Update #4 · Latest ·
AMENDMENT TO NICHD SOLICITATION, RFP NO: NIH-NICHD-IDD-2015-7
A Repository of Mouse Models for Cytogenetic Disorders
This amendment is issued to all potential Offerors.
THE FOLLOWING WILL BE ADDED TO SECTION G - CONTRACT ADMINISTRATION DATA:
ARTICLE G.__. REIMBURSEMENT PROCEDURES FOR SALE OF RESEARCH SUBSTANCES AND LIVING ORGANISMS
a. During the course of this contract, the Contracting Officer or his/her designated representative may notify the Contractor to make available to individuals and entities, for biomedical and behavioral research, research substances and living organisms. Such substances and organisms shall be made available under the terms and conditions (including payment for them) specified below and in SECTION C - DESCRIPTION/SPECIFICATIONS/WORK STATEMENT of this contract.
b. The Contractor shall bill recipients directly for the materials provided, including shipping and handling costs; however, the Contractor may be directed by the Contracting Officer or his/her designated representative to make such materials available free of charge.
c. The charges for these materials shall be based upon the current price list specified in SECTION C - DESCRIPTION/SPECIFICATIONS/WORK STATEMENT of this contract. Unless the Contractor is directed to make the materials available free of charge, under no circumstances shall the Contractor bill prices other than those included in the price list. The Government, without the concurrence of the Contractor, may revise the price of the materials being made available.
d. The Contractor shall keep an accurate account of all payments received from recipients from the sale of research substances and living organisms separate from other fiscal aspects of the contract and shall credit those payments to the Government by [TO BE DETERMINED] during the billing period in which they are received.
e. The Contractor shall submit to the Government a Monthly Summary of Sales, which is listed as an Attachment in SECTION J of this contract. The Contractor shall submit a copy of this Attachment each month with its invoice.
The administration of the proceeds from the sale research substances and living organisms shall be subject to the terms of this contract, including FAR Clause 52.215-2, Audit and Records-Negotiation, and its applicable Alternates.
PLEASE NOTE THE CUT OFF PERIOD FOR QUESTIONS FOR THIS ISSUE IS TUESDAY, JUNE 30th 2015 AT 2:00 P.M. LOCAL TIME.
Update #3 ·
Please disregard Attachment for Solicitation 1. Attachment for Solicitation 2 (RFP-NIH-NICHD-IDD-2015-7) replaces Solicitation 1.
Update #2 ·
Solicitation for Repository of Mouse Models for Cytogenetic Disorders for the IDD Branch of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) sponsors research and research training aimed at preventing and ameliorating intellectual and developmental disabilities.
Update #1 ·
The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Intellectual and Developmental Disabilities Branch (IDDB) has a requirement for a repository to develop and maintain mouse models of genetic diseases. The objective of this contract will be to develop and maintain animal models of genetic diseases with emphasis on trisomy 21 which has historically been to provide investigators with a consistent, reproducible source of animals for their studies. It is important that these investigators be assured that the contract provider has the required experience, personnel, or facilities and equipment to breed and refine methodologies to produce the various strains of mice available to these investigators and to maintain their genetic fidelity.
If selected for this requirement, the Contractor will breed mice and refine methodologies to produce the various strains of mice and to maintain their genetic fidelity.
The work will involve the following essential activities:
1) Breed various strains of mice with known genetic background, which will produce chromosomally unbalanced gametes, resulting in trisomic and monosomic embryos with special emphasis on chromosome 16, but including relevant regions of chromosome 17 and chromosome 10.
2) Establish a production facility to ensure that adequate breeding pairs of mice are available to meet the needs and interests of the research community engaged in studying other cytogenetic disorders aside from Down syndrome.
3) Refine procedures to cryopreserve embryos that will be rescued by thawing and re-implanting them in pseudo-pregnant mice.
4) Distribute the animal models to qualified investigators approved by the NICHD.
5) Test the animals periodically for pathogens as per standard protocols that are outlined in the standard operating procedures by the Contractor.
6) Characterize the clinical and neurobehavioral phenotype of the mouse models to ensure integrity of the strains and to allow for comparative phenotypic information among different murine strains using a standardized battery of tests, or as specified by the Project Officer.
7) Publicize the availability of mouse models indicating the type of strains in the colony as well as detailed information about the background strain, genotype, protocols for genotyping, husbandry conditions, phenotype and neurobehavioral characteristics, and other details as specified by the Project Officer.
As a result of this announcement the NICHD anticipates awarding a single cost reimbursement completion type contract with a period of performance of five years beginning on or about September 21, 2015. The NICHD anticipates the Request for Proposals (RFP) (NIH-NICHD-IDD-2015-7) for this study will be available through the Federal Business Opportunities website (https://www.fbo.gov/) on or about May 5, 2015. This acquisition has been designated as a full and open competition under North American Industry Classification System (NAICS) code is 541711 with a size standard of 500 employees. Any responsible offeror may submit a proposal that will be considered by the Government. Offerors are responsible for routinely checking the FedBizOpps website for any possible solicitation amendments that may be issued. This notice does not commit the Government to award a contract. No collect calls or facsimile transmissions will be accepted.
Contracting Office Address:
Contracts Management Branch
6100 Executive Blvd., Suite 7A07, MSC7510
Bethesda, Maryland 20892-7510
Contracting Office Address:
Contracts Management Branch
6100 Executive Blvd., Suite 7A07, MSC7510
Bethesda, Maryland 20892-7510
Files
| File | Type | Posted |
|---|---|---|
| Amendment_1_to_RFP_MMR.pdf | ||
| RFP_NIH-NICHD-IDD-2015-7.pdf | ||
| RFP_with_Attachments.pdf |
On GovTribe
Work this opportunity
- Track it in your pipeline
- Find teaming partners
- Similar opportunities
- Ask GovTribe AI about this opportunity