PKG00286000.pdf

This document is an Application Guide for NIH FORMS-H that directs applicants to use either General Instructions or Career Development Instructions when applying to the Mentored Quantitative Research Development Award (K25) Independent Clinical Trial Required funding opportunity. The K25 award, posted April 23, 2024 with a due date of May 7, 2027, is administered by the Department of Health and Human Services National Institutes of Health and seeks to attract quantitative researchers (with backgrounds in mathematics, statistics, economics, computer science, imaging science, informatics, physics, or chemistry) to NIH-relevant research by providing mentored support and protected time. Applicants must propose to serve as the lead investigator of an independent clinical trial, clinical trial feasibility study, or separate ancillary clinical trial. Eligible applicants include nonprofits, higher education institutions, state and local governments, small businesses, HBCUs, tribal colleges, faith-based organizations, and other specified entity types; foreign organizations and non-domestic components of U.S. organizations are not eligible, though foreign components within U.S. organizations are permitted. The award carries project durations of 2–5 years with award values historically ranging from approximately $35,000 to over $14 million in total costs. Research is conducted at recipient organization facilities across the United States. Applications are reviewed for scientific merit by peer review groups and program relevance by national advisory councils, with review timelines typically spanning 6–9 months. The funding opportunity is assigned to multiple federal grant programs including Trans-NIH Research Support (93.310), Cardiovascular Diseases Research (93.837), Lung Diseases Research (93.838), Blood Diseases and Resources Research (93.839), and others, reflecting its potential relevance across multiple NIH institutes and centers.