Sources Sought PCA-NIEHS-04776.docx

800 MHz NMR Console and Probe Sources Sought Notice # PCA-NIEHS-04776 Contracting Office Address Department of Health and Human Services, National Institutes of Health, Office of Acquisitions, OA Office of the Director, OD 6701 Rockledge Drive, Room 537-S, Bethesda, MD, 20892.

Introduction This is a notice issued on behalf of the National Institutes of Health (NIH), Office of Acquisitions, OA Office of the Director, OD, DHHS, UNITED STATES. This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this Sources Sought is to seek the availability and capability of small business concerns, including 8(a) small business and/or small qualified small business concerns [including Small Disadvantaged Businesses (SDB), Woman-owned Small Businesses (WOSB), Historically Underutilized Business Zone (HUBZone) Small Businesses, Veteran-Owned Small Businesses (VOSB) and Service-Disabled Veteran-owned Small Businesses (SDVOSB] that are interested in and capable of performing the work described in the statement of work. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible.

Background The National Institutes of Health (NIH), National Environmental Health Sciences (NIEHS) is seeking small businesses with the ability to provide 800 MHz NMR Console and Probe and associated components.

STATEMENT OF NEED:

The National Institute of Environmental Health Sciences (NIEHS) Genomics Core (NGC) utilizes the Bruker Spatial Biology nCounter Pro System to perform experiments that assess gene expression changes in biological samples. The continued operation, reliability, and performance of this instrument are essential to supporting ongoing research activities.

The primary objective of this contract is to acquire new upgraded equipment for the NMR Research Core Facility of the Division of Intramural Research, NIEHS, NIH based on research requirements determined by the Institute. The 800 MHz NMR system requires upgrades to maintain it in good working order for research conducted at NIEHS. The required system will interface with the existing 800 MHz Agilent 4K Compact magnet at NIEHS. The system will include in generalized terms: a new 4 channel console designed primarily for biomolecular NMR and interfaces, a new room temperature probe, a new helium cooled probe with required accessories, and potentially and HR-MAS probe. The system will need to interface with a temperature controlled automated sample changer.

NMR CONSOLE AVANCE NEO-X 800 MHZ SB

Bruker system characteristics (unified AQS/BSMS):

- 80 MHz system clock, 12.5ns timing resolution

- Synchronicity on all channels within 12.5ns

- Gradient control for all Bruker gradient amplifiers

- Up to 8 RF channels

- Up to 4 trigger inputs with 12.5ns resolution

- Up to 4 real time output controls with 12.5ns resolution

- Ultra-stable, ultra-low noise B0 current source (LOCK)

- 2G Digital NMR Lock for 2H and/or 19F nuclei (LOCK, L-TRV)

- Bruker Shim current sources (SCB20)

- Bruker SmartVT control for up to 4 independent VT channels

- Bruker High Resolution gradient amplifiers (e.g. GAB/3) Bruker preamplifier system (HPPR) supports:

- Up to 8 RF preamplifiers

- Fully Multi-receive, no extra wiring/components

- Touch screen based human machine interface

- Accurate tuning and matching with factory calibrated preamplifiers

- Fully integrated automatic tuning and matching with ATM probes

- Probe identification (PICS) interface Supported Units:

- Bruker SmartCoolers (e.g. BCU-I)

- Bruker Low Temperature accessories (e.g. LN2 Exchanger)

- Bruker High Temperature equipment (e.g. BVTE3900)

- Bruker RT Shim Systems and BST Upperparts

Period of Performance: This is a one-time supply acquisition with the duration of the maintenance agreement as specified in the resulting contract or purchase order.

Place of Performance: Services shall be performed at the NIEHS Genomics Core facility where the nCounter Pro System is installed, unless remote technical support is sufficient to resolve the issue.

Vendor shall provide manufacturer-authorized maintenance, service, technical support, and any necessary repairs for the nCounter Pro System. Services shall include preventive maintenance, troubleshooting, software and firmware updates (as applicable), replacement of manufacturer-approved parts, and technical assistance required to maintain the instrument in optimal operating condition. All services shall be performed by Bruker Spatial Biology-trained personnel using manufacturer-approved procedures and components to ensure the system continues to meet original performance specifications.

The Contractor shall provide all resources necessary to accomplish the tasks and deliverables described in this Statement of Work (SOW). Subject to prior approval of the Contracting Officer (CO), the Contractor may acquire the services of a subcontractor and/or consultants to provide specialized services if deemed appropriate and within scope by the COR.

The Contractor shall employ a technical approach, utilize organizational resources, and implement management controls to achieve the cost, schedule, and performance requirements throughout the execution of the Contract Requirements. The Contractor shall be responsible for providing, managing, and overseeing its personnel, as well as any subcontractor/consultant efforts used in the performance of the Contract Requirements.

This is intended to be a firm-fixed price contract.

Capability Statement Small business concerns that believe they possess the capabilities necessary to undertake this work should submit complete documentation of their capabilities to the Contracting Officer. The capability statement should include 1)Name and address of the vendor, 2) Size and type of business, 3) Point of contact with the name, title, phone, fax, and email, 4) UEI number. 5) the professional qualifications of experts, and technical personnel as it relates to the above outlined requirements, any other information considered relevant to this service. The capability statement must not exceed 7 pages. Interested small business organizations are required to identify their size standards in accordance with the Small Business Administration. The government requests that no proprietary or confidential business data be submitted in a response to this notice. However, responses that indicate the information therein is proprietary will be properly safeguarded for Government use only. Capability statements must include the name and telephone numbers of a point of contact having authority and knowledge to discuss responses with Government representatives. Capability statements in response to this market survey that do not provide sufficient information for evaluation will be considered non-responsive. When submitting this information, please reference the solicitation notice number.

Point of Contact:

Luz Casey, Program Specialist, Office of the Director, OD, Luz.Casey@nih.gov.

Department of Health and Human Services, National Institutes of Health, Office of Acquisition, Office of the Director, 6701 Rockledge Dr., Rm 537-S, Bethesda, MD 20892, USA Submission Instructions:

Interested parties shall submit capability statements via email to Luz Casey at Luz.Casey@nih.gov. Due Tuesday, September 9, 2026 @ 9:00 am EST.

All responses must be received by the specified due date and time in order to be considered.

This notice does not obligate the Government to award a contract or otherwise pay for the information provided in the response. No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization’s qualifications to provide the item. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After review of the responses received, pre-solicitation and solicitation notices will be published in GSA eBuy or SAM.gov. However, responses to this notice will not be considered adequate responses to a solicitation.