PAR-25-178-Full-Announcement.html

This is a Full Announcement (PAR-25-178) for a clinical trial grant opportunity from the National Institute of Mental Health (NIMH), under the Department of Health and Human Services. The funding supports pilot effectiveness studies focused on optimizing therapeutic and preventive interventions that have previously demonstrated efficacy, for broader populations or community practice settings, as well as developing innovative service delivery approaches.

The grant opportunity (Federal Grant Program 93.242 - Mental Health Research Grants) is open to a wide range of applicants including higher education institutions, state/local governments, tribal organizations, nonprofits, and small businesses. The program specifically requires that studies address the mechanisms underlying intervention effects, including changes in clinical outcomes, provider behavior, and service accessibility. All proposals must include a clinical trial component as part of the research design. The announcement represents part of NIMH's broader clinical trials pipeline initiative to advance mental health treatment and prevention strategies.