Attachment_I_Schedule_of_Milestones_and_Payments.xlsx

This is a Schedule of Milestones and Payments document outlining the deliverables and timeline for the DARPA Protein ENGineering (PENG) program across three phases spanning 42 months.

Phase 1A runs from Month 1 to Month 18 and requires five milestones: an initial in-person kickoff meeting with concept presentation, a Month 6 milestone report on editing efficiency and test data, a Month 9 report demonstrating editing against Phase 1 criteria for at least one self-chosen protein, a Month 12 on-site demonstration of editing capability with milestone report, and a Month 18 delivery of data packages to the Independent Verification & Validation (IV&V) team along with a final Phase 1A technical report and proof of Controlled Unclassified Information (CUI) compliance certification. Phase 1B spans Months 21-24 and includes three milestones: execution of adaptability testing on DARPA-chosen proteins with preliminary results presented during a site visit (Month 21), demonstration of functional editing of 2 of 3 DARPA-chosen proteins in cells or organoids with presentation and milestone report (Month 23), and delivery of Phase 1B data packages and technical reports documenting end-to-end protein editing capability (Month 24). Phase 2 runs from Month 30 to Month 42 and contains four milestones: a Month 30 report on integrating the protein editing platform into higher-order biological systems, a Month 33 go-to-market strategic plan addressing business models, techno-economic analysis, intellectual property protection, product packaging, markets, customers, partnerships, and funding needs, a Month 36 on-site demonstration with full package of results delivered to IV&V, and a Month 42 delivery of final technical reports, data packages, prototype of the protein editing pipeline, and transition partner briefing. Payment amounts are not specified in this template document.