07_-_EXHIBIT_B_-_List_of_Thresholds.pdf
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- Attached to
- Equine Drug Testing State and local contract opportunity
- Solicitation number
- EV00000668
- Issued by
- Oklahoma
About this file
This document is an Exhibit B detailing listed thresholds for drug and substance regulations for Quarter Horses, Paints, Appaloosas, and Thoroughbreds, issued by a regulatory agency overseeing horse racing and competition. The document comprehensively outlines specific concentration limits for various non-steroidal anti-inflammatories, corticosteroids, and androgenic-anabolic steroids in biological samples (plasma, serum, and urine) for different horse types and sexes. The regulations specify precise thresholds for substances like diclofenac, firocoxib, flunixin, ketoprofen, phenylbutazone, and naturally occurring substances such as boldenone, nandrolone, and testosterone.
The thresholds are differentiated by horse breed, sex, and specific biological sample type, with strict rules about permitted concentration levels. For instance, testosterone concentrations vary for fillies, mares, geldings, and male horses, with special provisions for pregnant mares and non-gelded males. The document also includes critical additional conditions, such as prohibiting the presence of more than one permitted non-steroidal anti-inflammatory or corticosteroid in a single biological sample. These detailed regulations appear designed to ensure fair competition and prevent performance enhancement through prohibited substance use in horse racing.
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Text version
(a) The thresholds listed in this section shall be considered the listed threshold for Permitted Substances or, if specified as such, Naturally Occurring Substances in Quarter Horses, Paints, and Appaloosas.
(b) Non-steroidal anti-inflammatories shall be considered Prohibited Substances except for the Chemicals listed below and their corresponding Analogs and Metabolites in concentrations not exceeding the listed threshold:
(1) Diclofenac: 5 ng/ml in Biological Samples consisting of Plasma or Serum;
(2) Firocoxib: 20 ng/ml in Biological Samples consisting of Plasma or Serum;
(3) Flunixin: 5 ng/ml in Biological Samples consisting of Plasma or Serum;
(4) Ketoprofen: 2 ng/ml in Biological Samples consisting of Plasma or Serum; or
(5) Phenylbutazone: .3 mcg/ml in Biological Samples consisting of Plasma or Serum.
(c) Corticosteroids shall be considered Prohibited Substances except for the Chemicals listed below and their corresponding Analogs and Metabolites in concentrations not exceeding the listed threshold:
(1) Betamethasone: 10 pg/ml in Biological Samples consisting of Plasma or Serum;
(2) Dexamethasone: 5 pg/ml in Biological amples consisting of Plasma or Serum;
(3) Isoflupredone: 100 pg/ml in Biological Samples consisting of Plasma or Serum;
(4) Methylprednisolone: 100 pg/ml in Biological Samples consisting of Plasma or Serum;
(5) Prednisolone: 1ng/ml in Biological Samples consisting of Plasma or Serum; or
(6) Triamcinolone Acetonide: 100 pg/ml in Biological Samples consisting of Plasma or Serum.
(d) Other substances shall be considered Prohibited Substances except for the Chemicals listed below and their corresponding Analogs and Metabolites in concentrations not exceeding the listed threshold:
(1) Acepromazine: 10 ng/ml in Biological Samples consisting of urine;
(2) Butorphanol: 300 ng/ml of total Butorphanol in Biological Samples consisting of urine or 2 ng/ml of free butorphanol in Biological Samples consisting of Plasma or Serum;
(3) Cetirizine: 6 ng/ml in Biological Samples consisting of Plasma or Serum;
(4) Cimetidine: 400 ng/ml in Biological Samples consisting of Plasma or Serum;
(5) Dantrolene: 100 pg/ml of 5-hydroxydantrolene in Biological Samples consisting of Plasma or
Serum;
(6) Detomidine: 1 ng/ml in Biological Samples consisting of Plasma or Serum;
(7) Dimethyl Sulfoxide (DMSO): 10 ug/ml in Biological Samples consisting of Plasma or Serum;
(8) Furosemide: 100 ng/ml in Biological Samples consisting of Plasma or Serum;
(9) Glycopyrrolate: 3 pg/ml in Biological Samples consisting of Plasma or Serum;
(10) Guaifenesin: 12 ng/ml in Biological Samples consisting of Plasma or Serum;
EXHIBIT B
325:45-1-6.2. Listed thresholds for Quarter Horses, Paints, and Appaloosas
(11) Lidocaine: 20 pg/ml of total 30H-lidocaine in Biological Samples consisting of Plasma or
Serum;
(12) Mepivacaine: 10 ng/ml in Biological Samples consisting of urine or at the level of detection in
Biological Samples consisting of Plasma or Serum;
(13) Methocarbamol: 1 ng/ml in Biological Samples consisting of Plasma or Serum;
(14) Omeprazole: omeprazole sulfide- 10 ng/ml in Biological Samples consisting of Plasma or
Serum;
(15) Procaine Penicillin: 25 ng/ml in Biological Samples consisting of Plasma or Serum;
(16) Ranitidine: 40 ng/ml in Biological Samples consisting of Plasma or Serum; or
(17) Xylazine: 200 pg/ml in Biological Samples consisting of Plasma or Serum.
(e) Androgenic-Anabolic Steroids (AAS) shall be considered Prohibited Substances except for the
Chemicals listed below and their corresponding Analogs and Metabolites in concentrations not exceeding the listed threshold:
(1) The Naturally Occurring Substance, boldenone, shall be permitted in concentrations not exceeding:
(A) 25 pg/ml in Biological Samples consisting of Plasma or Serum for all Horses, regardless of sex;
(B) 1 ng/ml in Biological Samples consisting of urine for fillies, mares, or geldings; or
(C) 15 ng/ml in Biological Samples consisting of urine for male Horses other than geldings.
(2) The Naturally Occurring Substance, nandrolone, shall be permitted in concentrations not exceeding:
(A) 25 pg/ml in Biological Samples consisting of Plasma or Serum for fillies, mares, and geldings;
(B) 1 ng/ml in Biological Samples consisting of urine for fillies, mares, or geldings; or
(C) 45 ng/ml in Biological Samples consisting of urine for male Horses other than geldings.
(3) The Naturally Occurring Substance, testosterone, shall be permitted in concentrations not exceeding:
(A) 100 pg/ml in Biological Samples consisting of Plasma or Serum for fillies, mares, and geldings;
(B) 55 ng/ml in Biological Samples consisting of urine for fillies, mares (unless in foal); or
(C) 20 ng/ml in Biological Samples consisting of urine for geldings.
(D) The concentration of testosterone is not regulated or restricted in fillies or mares that are confirmed pregnant on the day of racing or in male Horses other than geldings.
(f) The use of non-steroidal anti-inflammatories and corticosteroids are subject to the additional conditions:
(1) The presence of more than one permitted non-steroidal anti-inflammatories in a Biological
Sample consisting of Plasma or Serum is prohibited; or
(2) The presence of more than one corticosteroids in a Biological Sample consisting of Plasma or
Serum is prohibited.
325:45-1-6.1. Listed thresholds for Thoroughbreds
(a) The thresholds listed in this section shall be the considered listed threshold for Permitted Substances or, if specified as such, Naturally Occurring Substances in Thoroughbreds.
(b) Non-steroidal anti-inflammatories shall be considered Prohibited Substances except for the Chemicals listed below and their corresponding Analogs and Metabolites in concentrations not exceeding the listed threshold:
(1) Diclofenac: 5 ng/ml in Biological Samples consisting of Plasma or Serum;
(2) Firocoxib: 20 ng/ml in Biological Samples consisting of Plasma or Serum;
(3) Flunixin: 5 ng/ml in Biological Samples consisting of Plasma or Serum;
(4) Ketoprofen: 2 ng/ml in Biological Samples consisting of Plasma or Serum; or
(5) Phenylbutazone: .3 mcg/ml in Biological Samples consisting of Plasma or Serum.
(c) Corticosteroids shall be considered Prohibited Substances except for the Chemicals listed below and their corresponding Analogs and Metabolites in concentrations not exceeding the listed threshold:
(1) Betamethasone: 10 pg/ml in Biological Samples consisting of Plasma or Serum;
(2) Dexamethasone: 5 pg/ml in Biological Samples consisting of Plasma or Serum;
(3) Isoflupredone: 100 pg/ml in Biological Samples consisting of Plasma or Serum;
(4) Methylprednisolone: 100 pg/ml in Biological Samples consisting of Plasma or Derum;
(5) Prednisolone: 1ng/ml in Biological Samples consisting of Plasma or Serum; or
(6) Triamcinolone Acetonide: 100 pg/ml in Biological Samples consisting of Plasma or Serum.
(d) Other substances shall be considered Prohibited Substances except for the Chemicals listed below and their corresponding Analogs and Metabolites in concentrations not exceeding the listed threshold:
(1) Acepromazine: 10 ng/ml in Biological Samples consisting of urine;
(2) Albuterol: 1 ng/ml in Biological Samples consisting of urine;
(3) Butorphanol: 300 ng/ml of total Butorphanol in Biological Samples consisting of urine or 2 ng/ml of free butorphanol in Biological Samples consisting of Plasma or Derum;
(4) Cetirizine: 6 ng/ml in Biological Samples consisting of Plasma or Serum;
(5) Cimetidine: 400 ng/ml in Biological Samples consisting of Plasma or Serum;
(6) Clenbuterol: 140 pg/ml in Biological Samples consisting of urine or at the level of detection in
Biological Samples consisting of Plasma or Serum;
(7) Dantrolene: 100 pg/ml of 5-hydroxydantrolene in Biological Samples consisting of Plasma or
Serum;
(8) Detomidine: 1 ng/ml in Biological Samples consisting of Plasma or Serum;
(9) Dimethyl Sulfoxide (DMSO): 10 ug/ml in Biological Samples consisting of Plasma or Serum;
(10) Furosemide: 100 ng/ml in Biological Samples consisting of Plasma or Serum;
(11) Glycopyrrolate: 3 pg/ml in Biological Samples consisting of Plasma or Serum;
(12) Guaifenesin: 12 ng/ml in Biological Samples consisting of Plasma or Serum;
(13) Lidocaine: 20 pg/ml of total 30H-lidocaine in Biological Samples consisting of Plasma or
Serum;
(14) Mepivacaine: 10 ng/ml in Biological Samples consisting of urine or at the level of detection in
Biological Samples consisting of Plasma or Serum;
(15) Methocarbamol: 1 ng/ml in Biological Samples consisting of Plasma or Serum;
(16) Omeprazole: omeprazole sulfide- 10 ng/ml in Biological Samples consisting of Plasma or
Serum;
(17) Procaine Penicillin: 25 ng/ml in Biological Samples consisting of Plasma or Serum;
(18) Ranitidine: 40 ng/ml in Biological Samples consisting of Plasma or Serum; or
(19) Xylazine: 200 pg/ml in Biological Samples consisting of Plasma or Serum.
(e) Androgenic-Anabolic Steroids (AAS) shall be considered Prohibited Substances except for the
Chemicals listed below and their corresponding Analogs and Metabolites in concentrations not exceeding the listed threshold:
(1) The Naturally Occurring Substance, boldenone, shall be permitted in concentrations not exceeding:
(A) 25 pg/ml in Biological Samples consisting of Plasma or Serum for all Horses, regardless of sex;
(B) 1 ng/ml in Biological Samples consisting of urine for fillies, mares, or geldings; or
(C) 15 ng/ml in Biological Samples consisting of urine for male Horses other than geldings.
(2) The Naturally Occurring Substance, nandrolone, shall be permitted in concentrations not exceeding:
(A) 25 pg/ml in Biological Samples consisting of Plasma or Serum for fillies, mares, and geldings;
(B) 1 ng/ml in Biological Samples consisting of urine for fillies, mares, or geldings; or
(C) 45 ng/ml in Biological Samples consisting of urine for male Horses other than geldings.
(3) The Naturally Occurring Substance, testosterone, shall be permitted in concentrations not exceeding:
(A) 100 pg/ml in Biological Samples consisting of Plasma or Serum for fillies, mares, and geldings;
(B) 55 ng/ml in Biological Samples consisting of urine for fillies, mares (unless in foal); or
(C) 20 ng/ml in Biological Samples consisting of urine for geldings.
(D) The concentration of testosterone is not regulated or restricted in fillies or mares that are confirmed pregnant on the day of racing or in male Horses other than geldings.
(f) The use of non-steroidal anti-inflammatories and corticosteroids are subject to the additional conditions:
(1) The presence of more than one permitted non-steroidal anti-inflammatories in a Biological
Sample consisting of Plasma or Serum is prohibited; or
(2) The presence of more than one corticosteroid in a Biological Sample consisting of Plasma or
Serum is prohibited.
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