Exploiting DNA repair defects in krebs cycle-deficient renal cell carcinoma

Ended Project Grant Awarded Last action

Award ID
W81XWH2210549
Recipient
Awarding agency
Obligated
$1,562,318

Award facts

Assistance listing
12.420 Military Medical Research and Development
Completion date
Funding
  • $781,159.00 Federal
  • $781,159.00 Non-federal
Place of performance
Los Angeles, CA 90024, USA

Award details come from USAspending.gov.

About this award

Written by GovTribe AI ·

The University of California, Los Angeles (UCLA) was awarded a $1.56 million Project Grant from the Department of the Army Medical Command under the Military Medical Research and Development program (CFDA 12.420) for the period of June 30, 2022 to June 29, 2025.

The grant will support research to exploit DNA repair defects in renal cell carcinoma that is deficient in Krebs cycle enzymes. Specifically, the university will identify efficacious combinations of DNA damage response inhibitors in isogenic cell lines that differ only in fumarate hydratase and succinate dehydrogenase status. Yale University was awarded a sub-grant to evaluate prioritized combination approaches in additional isogenic and patient-derived cell lines. The research aims to transform healthcare for service members and the public through innovative medical solutions for treating battlefield injuries and cancer.

Subawards

Subrecipient Amount Awarded
Yale Univ Major Task 1: Identify efficacious DDR inhibitor-based combinations in isogenic matched cell lines (differing only by FH and SDH status)Major Task 2: Evaluate… $301,501

Quick answers

Who received award W81XWH2210549?

W81XWH2210549 was awarded to University Of California, LOS Angeles by Medical Command (Department of the Army) on June 30, 2022.

How much is award W81XWH2210549 worth?

$1,562,318 has been obligated on W81XWH2210549: $781,159 in federal funding and $781,159 in non-federal funding.

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