Biomarkers of response to combination cabozantinib + nivolumav in advanced renal cell carcinoma
Ended Project Grant Awarded Last action
- Award ID
- W81XWH2210518
- Recipient
-
Dana-Farber Cancer Institute, Inc. UEI DPMGH9MG1X67
- Awarding agency
-
Medical Command
Department of the Army, Department of Defense
- Obligated
- $1,335,000
Award facts
- Assistance listing
- 12.420 Military Medical Research and Development
- Completion date
- Funding
-
- $667,500.00 Federal
- $667,500.00 Non-federal
- Place of performance
- Boston, MA 02115, USA
Award details come from USAspending.gov.
About this award
This three-year, $1.335 million Project Grant from the Department of the Army Medical Command, under the Military Medical Research and Development program (CFDA 12.420), will support biomarkers research of response to combination cabozantinib and nivolumab treatment in advanced renal cell carcinoma. The grantee, Dana-Farber Cancer Institute, will analyze whole exome sequencing, RNA sequencing, and clinical outcome data to identify genetic alterations and gene expression signatures that impact response to the combination immunotherapy and targeted therapy. Sub-awardee Yale University will assist in the analysis and interpretation of the genomic and transcriptomic data, including gene signature analysis, immune cell deconvolution, and evaluation of specific genetic alterations like 9p21.3 deletion on clinical outcomes. The grant aims to transform cancer care for service members and the public through innovative biomarker research identifying medical solutions for renal cell carcinoma.
Transactions
| Action | Federal | Non-federal | Date |
|---|---|---|---|
| Amendment | $0 | $0 | |
| Original award | $667,500 | $667,500 |
Quick answers
Who received award W81XWH2210518?
W81XWH2210518 was awarded to Dana-Farber Cancer Institute, Inc. by Medical Command (Department of the Army) on July 1, 2022.
How much is award W81XWH2210518 worth?
$1,335,000 has been obligated on W81XWH2210518: $667,500 in federal funding and $667,500 in non-federal funding.
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