Regulatory t-cell expansion and immune modulation in vascularized composite tissue transplants

The Massachusetts General Hospital was awarded a $999,792 Project Grant from the Department of the Army Medical Command under the Military Medical Research and Development program (CFDA 12.420). The grant will fund research into regulatory T-cell expansion and immune modulation in vascularized composite tissue transplants from September 15, 2021 through September 14, 2024.

The Military Medical Research and Development program supports biomedical research that transforms military and public health care through innovative solutions. This award will investigate medical solutions for transplant rejection, advancing the program's goal to develop treatments for wounded soldiers and the general public. Massachusetts General Hospital will conduct research over three years to better understand and modulate immune responses following complex tissue transplantation. Insights from this work could help improve outcomes for combat casualties and other patients requiring composite tissue replacement.