Further optimizing 2ND generation dual-targeted fine-tuned immune-restoring (dfir) car t cells to achieve cures of advanced ccrcc
Ended Project Grant Awarded Last action
- Award ID
- W81XWH2110482
- Recipient
-
Dana-Farber Cancer Institute, Inc. UEI DPMGH9MG1X67
- Awarding agency
-
Defense Health Agency
Department of Defense
- Obligated
- $979,875
Award facts
- Assistance listing
- 12.420 Military Medical Research and Development
- Completion date
- Place of performance
- Boston, MA 02115, USA
Award details come from USAspending.gov.
About this award
This Project Grant award from the Defense Health Agency provides $979,875 to Dana-Farber Cancer Institute, Inc. for research under the Military Medical Research and Development program. The award aims to further optimize dual-targeted CAR T cells to achieve cures for advanced clear cell renal cell carcinoma (CCRCC) by fine-tuning CAR constructs against carbonic anhydrase IX and CD70 antigens based on tumor expression levels. Brigham and Women's Hospital, Inc. will receive a sub-award to quantitatively analyze antigen expression in advanced CCRCC patient samples and determine CAR affinity levels suitable for various tumor phenotypes. This research seeks to account for tumor heterogeneity and potentially restore anti-tumor activity through CAR payloads targeting immune checkpoint blockade. The award period is from September 1, 2021 through August 31, 2023.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Original award | $979,875 |
Quick answers
Who received award W81XWH2110482?
W81XWH2110482 was awarded to Dana-Farber Cancer Institute, Inc. by Defense Health Agency (Department of Defense) on September 1, 2021.
How much is award W81XWH2110482 worth?
$979,875 has been obligated on W81XWH2110482.
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