The National Institute of General Medical Sciences (NIGMS) has awarded a $492,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Princeton University. The grant, which runs from Sep 1, 2024 to Aug 31, 2029, supports research aimed at accessing previously hidden sources of microbial natural products and investigating their structures, functions, therapeutic uses, and biosynthetic pathways. Key objectives include eliciting cryptic metabolites from...
The National Institute of General Medical Sciences (NIGMS) awarded a $737,648 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Florida. The grant will fund research to explore fundamental mechanisms underlying interactions between the human microbiome and the extracellular matrix (ECM) in tissues, and how microbiota-driven ECM remodeling impacts host immune cell function. The proposed work will utilize in vitro and ex vivo models with...
The National Institute of General Medical Sciences (NIGMS) awarded a $382,136 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Maryland, College Park. The five-year grant, effective May 1, 2025 through March 31, 2030, supports research to define engineering principles for designing programmable bioengineered multicellular structures (probioms) in prokaryotic cells. The goal is to develop these probioms, modeled after natural probiotic...
The National Institute of General Medical Sciences (NIGMS) awarded a $275,303 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Pittsburgh. The grant will fund a 5-year research project to develop predictive stochastic models that bridge the molecular, cellular, and population scales of microbial proliferation and population dynamics. Specifically, the research aims to: (i) understand the effects of molecular noise on microbial cell size...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $422,931 to characterize the role of specialized microbial metabolites in mediating interactions within the human microbiome. The award aims to integrate cheminformatics analysis of metabolomics data with in vitro model systems to elucidate novel chemistry that influences the structure and function of the microbiome, including...
This Project Grant award of $446,875.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research at the University of Pennsylvania to investigate the roles of different types of mucosal immunoglobulins (IgA and IgM) in regulating gut microbiome homeostasis and metabolism. The research aims to elucidate the unique and synergistic physical and functional consequences of IgA and IgM binding to the gut...
This Project Grant award, valued at $133,246, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The funding will support the development of flexible Bayesian statistical methods to gain a comprehensive understanding of microbial community dynamics using high-throughput sequencing data. The key objectives are to create a general method for inferring microbial community dynamics that vary with...
This Project Grant award, with a total funding amount of $238,500, was provided by the U.S. Department of Agriculture's National Institute of Food and Agriculture through the Higher Education National Needs Graduate Fellowship Grants program (CFDA 10.210). The grant will establish one of the first graduate training programs at the intersection of microbiome sciences and reproductive biology in agriculturally important animals. Three PhD fellows will receive broad training in areas such as animal...
The National Institute of General Medical Sciences (NIGMS) awarded a $148,880 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Pennsylvania State University (Penn State) on December 1, 2024. The funding will support research to elucidate the role of metal cofactors in the GDGT-MAS enzyme, which facilitates the formation of carbon-carbon bonds from inert carbons - a rare biological capability. The research aims to characterize the spectroscopic and...
This federal Project Grant award of $854,736, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop a comprehensive suite of statistical tools for analyzing longitudinal microbiome studies. The key products and services to be delivered include: Methods for addressing batch effects in longitudinal microbiome data, which is a critical issue as studies grow larger or integrated. Improved...
The National Institute of General Medical Sciences (NIGMS) awarded a $534,450 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) federal grant program to The Pennsylvania State University (Penn State) for the "Biotechnological and Integrative Opportunities in Microbiome Sciences (BIOMS)" predoctoral training program. The BIOMS program will establish the first NIH T32 training program dedicated exclusively to educating graduate students in microbiome sciences and its biotechnological applications. Over 5 years, the program aims to train a minimum of 28 fellows, generally in years 2 and 3 of their PhD studies. The program will provide fellows with skills and knowledge to advance microbiome biotechnology, including technologies for microbial discovery, probiotics, antimicrobials, diagnostics, and transplant therapies. The training will leverage the resources of Penn State's One Health Microbiome Center to deliver a comprehensive curriculum, workshops, seminars, and professional development experiences to prepare fellows to be leaders in the growing microbiome biotechnology field.