This federal Project Grant award, identified as R35GM152049, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program. The $492,000 award supports a 5-year research project conducted by The Trustees of Princeton University that aims to expand the chemical space of microbial and microbiome natural products. Key objectives include elucidating cryptic metabolites in diverse microbial genera, especially...
This Project Grant award of $406,250.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to investigate the role of mechanical cues in the extracellular matrix in regulating monocyte inflammation. The project aims to develop human stem cell-based culture systems for studying monocyte mechanobiology, investigate the mechanical regulation of non-canonical NF-kappa-B signaling both in vitro...
The University of Pennsylvania was awarded a $852,726 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) by the National Institute of General Medical Sciences (NIGMS) within the National Institutes of Health. The grant supports the development of quantitative, multiplexed super-resolution microscopy methods to visualize and analyze the multi-scale spatial organization of cellular components, including organelle transport, protein assemblies, and chromatin...
The National Institute of General Medical Sciences (NIGMS) awarded a $406,250 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) federal grant program to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania. This 5-year award, effective January 22, 2025, supports research to implement a "nascent extracellular matrix" into engineered in vitro cellular systems, in order to better understand...
This Project Grant award of $403,750.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) program, aims to unravel the effects of gut and blood microbial signatures on immune phenotypes and organ dysfunction in sepsis. The award supports a prospective longitudinal cohort study at Duke University that will integrate gut microbial community profiling, metabolomics, measures of intestinal permeability, and blood...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,140,912 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) program to the University of North Carolina at Chapel Hill. The 5-year grant, effective from August 1, 2024 to July 31, 2029, will support research to understand host-microbiome coevolution and genetic variation in immunity using an insect model system. The research program takes advantage of the pea aphid, an insect that reproduces...
This Project Grant award, valued at $133,246, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The funding will support the development of flexible Bayesian statistical methods to gain a comprehensive understanding of microbial community dynamics using high-throughput sequencing data. The key objectives are to create a general method for inferring microbial community dynamics that vary with...
This Project Grant award, totaling $216,736.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research project aims to identify the mechanisms by which the host circadian clock and gut microbiome regulate mucus production in the large intestine to protect against infectious and chemical colitis. Key objectives include determining the specific microbiota...
This federal Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) provides $406,250.00 to The Trustees of the University of Pennsylvania over a 5-year period from August 15, 2024 to July 31, 2029. The research focuses on mapping the post-transcriptional aspects of gene expression, with a specific emphasis on understanding alternative ribosome initiation and the role of RNA modifications and binding proteins in...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $224,807 to the University of California, Irvine (UCI) to conduct research on identifying and engineering microbial enzymes that can modulate peptidoglycan (PG) metabolite levels in the gut microbiome. The goals are to discover highly active, secreted, and stable PG-degrading enzymes (Aim 1) and develop genetic tools...
This Project Grant award, totaling $446,875.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program. The grant supports research to determine the unique and synergistic physical and functional consequences of different secretory immunoglobulin (Ig) isotypes targeting the human gut microbiota. The research aims to uncover novel mechanisms by which Ig-coating of the microbiota regulates microbial colonization, gene expression, and metabolism, with the potential to identify new microbiome-targeted interventions for human diseases associated with microbiome dysregulation. The award is being provided to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania, a prominent private research university in Philadelphia, and will run from July 1, 2025 through April 30, 2030.